65854-97-9 Usage
Uses
Used in Pharmaceutical Industry:
5,5-Diphenyl-d10-Hydantoin is used as an internal standard for the quantification of Phenytoin by GCor LC-mass spectrometry. This application is crucial for ensuring accurate and precise measurements of Phenytoin levels in various pharmaceutical formulations and biological samples.
Used in Neurology:
5,5-Diphenyl-d10-Hydantoin is used as an anticonvulsant agent for the treatment of various neurological conditions, such as grand mal seizures, ulcers, epidermolysis bullosa, chorea, Parkinson's syndrome, trigeminal neuralgia, acute alcoholism, and inflammatory conditions. It appears to stabilize excitable membranes, potentially through effects on Na+, K+, and Ca2+ channels, thereby reducing the incidence of seizures and alleviating symptoms associated with these conditions.
Used in Research:
5,5-(Diphenyl-d10) Hydantoin serves as a valuable research tool in the study of the mechanisms of action and pharmacokinetics of Diphenylhydantoin and related anticonvulsant drugs. Its deuterium-labeled nature allows for the differentiation between the endogenous compound and the labeled analog, facilitating the investigation of drug metabolism, distribution, and excretion.
Check Digit Verification of cas no
The CAS Registry Mumber 65854-97-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,8,5 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 65854-97:
(7*6)+(6*5)+(5*8)+(4*5)+(3*4)+(2*9)+(1*7)=169
169 % 10 = 9
So 65854-97-9 is a valid CAS Registry Number.
65854-97-9Relevant academic research and scientific papers
Synthesis of deuterium-labelled drugs by hydrogen-deuterium (H-D) exchange using heterogeneous catalysis
Modutlwa, Nkaelang,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
experimental part, p. 686 - 692 (2011/09/16)
Multi-deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post-synthetically achieved by Pd/C-, Pt/C-, or/and Rh/C-catalyzed hydrogen-deuterium exchange reactions under neutral conditions usin
Superacid Activated Condensation of Parabanic Acid and Derivatives with Arenes. A New Synthesis of Phenytoin and 5,5-Diarylhydantoins
Klumpp, Douglas A.,Yeung, Ka Yeun,Prakash, G. K. Surya,Olah, George A.
, p. 918 - 920 (2007/10/03)
A new synthetic route to phenytoin and 5,5-diarylhydantoins is repoted.Parabanic acid is converted to the 5,5-diarylhydantoins (65-98percent yield) from CF3SO3H and arenes.Deuterium substituted products are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.
