65864-23-5

Upstream product

• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 60058-69-7 (tert-butyloxycarbonyl)-β-benzyl-L-aspartyl-L-phenylalanine amide 

Downstream Products

• 27168-83-8 Boc-Trp-Lys-Asp-Phe-NH₂ 
• 131450-41-4 (S)-3-{(S)-6-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester 
• 131450-19-6 Boc-Trp-homolysine(N^ω-2-methylphenylaminocarbonyl)-Asp-Phe-NH2 
• 131450-40-3 H-Lys(CBz)-Asp(OBn)-Phe-NH₂ hydrochloride 
• 131450-16-3 Boc-Trp-Orn(N^γ-2-methylphenylaminocarbonyl)-Asp-Phe-NH2 
• 135257-11-3 Boc-Trp-homoLys-Asp-Phe-NH₂ 
• 129594-04-3 Boc-Trp-Orn-Asp-Phe-NH₂ 
• 131450-39-0 Boc-Lys(Cbz)-Asp(OBzl)-Phe-NH₂ 

Relevant academic research and scientific papers

Process for the preparation of azacycloalkylakanoyl pseudotetrapeptides

This invention is directed to a process for preparing a pseudotetrapeptide of formula I or a salt or prodrug thereof wherein is optionally nitrogen protected azaheterocyclyl; is a single or double bond; q is 1-5; B is alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, aralkyl, alkylaryl, or alkylaralkyl; Q2 is H or a carboxylic acid protecting group; J is —H, alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl; L is OR1, or NR1R2, where R1 and R2 are independently —H, alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, aryl, aralkyl, alkylaryl or alkylaralkyl; and p is 1 or 2 which comprises the coupling of two dipeptides or psuedopeptides.

Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists

Novel Boc-CCK-4 derivatives were communicated recently as having high potency and selectivity for the CCK-A receptor (Shiosaki et al. J. Med. Chem. 1990, 33, 2950-2952). While Boc-CCK-4 binds selectively to the CCK-B receptor, replacement of the methionin