658686-30-7

Basic information

• Product Name: 2(1H)-Quinoxalinethione,3-ethyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinethione,3-ethyl-(9CI);3-ETHYLQUINOXALINE-2(1H)-THIONE
• CAS NO: 658686-30-7
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.26
• Product Categories: PIPERIDINE
• Mol File: 658686-30-7.mol

Chemical Properties

• Boiling Point: 324.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 8.74±0.70(Predicted)
• CAS DataBase Reference: 2(1H)-Quinoxalinethione,3-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinethione,3-ethyl-(9CI)(658686-30-7)
• EPA Substance Registry System: 2(1H)-Quinoxalinethione,3-ethyl-(9CI)(658686-30-7)

Safety Data

• Hazardous Substances Data: 658686-30-7(Hazardous Substances Data)

Usage

Physical State

Yellow solid

Molecular Weight

191.25 g/mol

Biological Activities

Antimicrobial, antifungal, and antiviral properties

Potential Applications

Synthesis of pharmaceuticals and agrochemicals, treatment of cancer and neurological disorders, study of biological and pharmacological properties

Versatility

Wide range of biological activities, potential applications in various fields

Upstream product

• 58773-29-8 3-methyl-1,2-dihydroquinoxaline-2-thione 
• 74-88-4 methyl iodide 

Relevant articles and documents

A Convenient Procedure for the Synthesis of Novel Modified 3-Substituted 1H-Quinoxaline-2-thiones via Side-Chain Lithiation of 3-Alkyl-1H-quinoxaline-2- thiones

3-Methyl-1H-quinoxaline-2-thione (1) has been doubly lithiated, at nitrogen and at the 3-methyl group, with n-butyllithium at -78°C in THF. The resulting dilithium reagent obtained reacts with a variety of electrophiles (iodomethane, iodoethane, 1-bromobutane, D2O, benzaldehyde, anisaldehyde, 2-hexanone, cyclohexanone, benzophenone, phenyl isothiocyanate) to give the corresponding modified 3-substituted 1H-quinoxaline-2-thiones 4-13 in high yields. Similarly, double lithiation of 3-ethyl- (4) and 3-propyl-1H-quinoxaline-2-thiones (5), followed by reaction with some electrophiles gave the corresponding modified 3-substituted derivatives 15-19 in high yields. Treatment of some of the products with trifluoroacetic acid in dichloromethane at room temperature led to formation of substituted 2,3-dihydrothieno[2,3-b]quinoxalines in good yields.