658709-75-2Relevant academic research and scientific papers
Rapid selective defunctionalization of the carbonyl group of α,β-unsaturated ketones with trialkoxylsilane/ZnX2
Li, Jiayun,Peng, Jiajian,Bai, Ying,Chen, Lingzhen,Lai, Guoqiao
scheme or table, p. 1621 - 1625 (2011/10/04)
Reduction of the carbonyl group of ketones to a methylene unit is widely applied in organic syntheses. In this article, we report that trialkoxylsilane/Zn-based catalyst systems may be applied in the reduction of the carbonyl groups of α,β-unsaturated ketones to methylene units under very mild conditions. In comparison with other Zn-based catalysts, excellent rates and high conversions of,-unsaturated ketones to methylene units are obtained using trialkoxylsilane/ZnI2 or ZnCl2. And the same time, the hydrosilylation reaction product could only be detected when using CuI, CuCl, or FeCl3. No reaction could be conducted by using trialkoxylsilane/CoCl2 or NiCl2, in comparison with Zn-based catalysts. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor &Francis Group, LLC.
