65871-42-3

Upstream product

• 40642-55-5 2-chloro-5-(2-methylphenyl)-1,3,4-thiadiazole 
• 108-24-7 acetic anhydride 
• 59758-33-7 2-hydrazino-5-(2-methylphenyl)-1,3,4-thiadiazole 

Downstream Products

• 104071-70-7 2-(2-acetyl-1-benzylhydrazino)-5-(2-methylphenyl)-1,3,4-thiadiazole 
• 104070-63-5 2-(1-benzylhydrazino)-5-(2-methylphenyl)-1,3,4-thiadiazole 
• 104071-44-5 N-Benzyl-N'-methyl-N-(5-o-tolyl-[1,3,4]thiadiazol-2-yl)-hydrazine; hydrochloride 
• 104071-17-2 N-Benzyl-N',N'-dimethyl-N-(5-o-tolyl-[1,3,4]thiadiazol-2-yl)-hydrazine 
• 104071-03-6 2-(1-benzyl-2-ethylhydrazino)-5-(2-methylphenyl)-1,3,4-thiadiazole 
• 104070-59-9 2-(N-methyl-hydrazino)-5-o-tolyl-[1,3,4]thiadiazole 
• 65871-43-4 acetic acid N-methyl-N'-(5-o-tolyl-[1,3,4]thiadiazol-2-yl)-hydrazide 

Relevant academic research and scientific papers

Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 1. Hydrazines

The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described.The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.