65872-12-0

Usage

Structure

A pyridine ring with a hydroxyl group at position 1 and a thione functional group at position 3

Derivative of

Pyridine ring

Functional groups

Hydroxyl group, thione functional group

Potential applications

Chelating agent, synthesis of organic compounds, pharmaceutical and chemical industries

Biological activity

Antioxidant and antimicrobial properties (studies suggest)

Further research needed

To fully understand the potential uses and effects of the compound.

Upstream product

• 1073-34-3 4-chloro-3-methylpyridine-1-oxide 

Relevant academic research and scientific papers

PYRIDINE THIO DERIVATIVE, AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAME AND HAS ANTI-HELICOBACTER PYLORI ACTION

Disclosed are a novel pyridine thio derivative, and a pharmaceutical composition using the novel pyridine thio derivative, particularly a pharmaceutical composition having selective antibacterial activity against Helicobacter pylori. Specifically disclosed is a pyridine thio derivative represented by general formula (I) (wherein R1 and R2 each represents a hydrogen atom, a C1-8 alkyl group or the like; R3 and R4 each represents a hydrogen atom, a C1-8 alkyl group or the like; X represents —O—, —S— or the like; Y represents a C1-12 alkyl group which may be substituted by a substituent or —(R5—O)n—R6 (wherein R5 represents a C1-5 alkylene group; R6 represents a C1-8 alkyl group which may be substituted by a substituent, and n represents an integer of 1-10); and Z represents a hydrogen atom or the like), or a pharmacologically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing the pyridine thio derivative or a salt thereof.

PYRIDINE COMPOUNDS AND METHODS OF THEIR USE

Novel pyridine compounds, pharmaceutical compositions containing the pyridine compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the pyridine compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.