65876-30-4

Usage

Type of compound

piperazine derivative

Potential effects

neuroprotective and antidepressant

Target receptors

serotonin and dopamine in the brain

Mechanism of action

modulates neurotransmitter activity involved in mood regulation and emotional processing

Additional properties

potential anti-inflammatory and antioxidant effects

Potential use

development of novel psychiatric medications

Area of research

neuropharmacology

Upstream product

• 39512-51-1 1-(o-toluyl)piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 61015-47-2 3-(4-o-tolyl-piperazin-1-yl)-propionamide 
• 72822-26-5 3-(4-o-tolyl-piperazin-1-yl)-propionic acid 
• 90619-35-5 2-[3-(4-o-Tolyl-piperazin-1-yl)-propyl]-3a,4,7,7a-tetrahydro-isoindole-1,3-dione; hydrochloride 
• 90619-42-4 1,8,8-Trimethyl-3-[3-(4-o-tolyl-piperazin-1-yl)-propyl]-3-aza-bicyclo[3.2.1]octane-2,4-dione; hydrochloride 
• 79323-02-7 4-(4-Methoxy-phenyl)-1-[3-(4-o-tolyl-piperazin-1-yl)-propyl]-piperidine-2,6-dione 
• 20529-21-9 3-[4-(o-tolyl)piperazin-1-yl]propan-1-amine 

Relevant academic research and scientific papers

Triethylammonium acetate (TEAA): A recyclable inexpensive ionic liquid promotes the chemoselective aza- and thia-Michael reactions

A new, highly efficient, inexpensive, recyclable, mild, convenient, and green protocol for chemoselective aza/thia-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using triethylammonium acetate (TEAA) ionic liquid was developed. The catalyst can be recycled ten times and obviate the need for toxic and expensive catalysts.

Cu-nanoparticles: A chemoselective catalyst for the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile

A novel method for effecting the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile using Cu-nanoparticles is described. The method features the use of 10 mol % Cu (14-17 nm) nanoparticles under mild reaction conditions to afford the addition products in good to excellent yields. The Cu-nanoparticles selectively catalysed the aza-Michael reaction of N-alkyl- and N-arylpiperazines in the presence of aromatic amino or aliphatic hydroxy groups.