65877-42-1Relevant academic research and scientific papers
Total synthesis of (+)-4-demethoxydaunomycin
Ayyangar, N R,Argade, A B,Mehendale, A R,Deshpande, V H
, p. 377 - 384 (2007/10/02)
Starting from commercially available dyestuff intermediate, quinizarin (6) as BCD-ring synthon for anthracycline, a key intermediate 5b has been prepared by a simple reaction sequence. (+/-)-4-Demethoxydaunomycinone (4b) has been synthesized from 5b.Further 4b was coupled with L-daunosamine derivative (24) to give the requisite α-glycoside 4a.
