65882-00-0Relevant articles and documents
INHIBITORS OF VAP-1
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Paragraph 0439, (2020/05/12)
Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors
Heitsch, Holger,Wagner, Adalbert,Schoelkens, Bernward A.,Wirth, Klaus
, p. 327 - 332 (2007/10/03)
The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations.
Synthesis of Indolin-2-ones (Oxindoles) Related to Mitomycin A
Raphael, Ralph A.,Ravenscroft, Paul
, p. 1823 - 1828 (2007/10/02)
Oxindoles (indolin-2-ones) containing the functionality of the first two rings of the mytomicin A structure have been synthesized.Attempts to employ the oxindole grouping to construct the third ring were unsuccessful because of the resistance of the oxindole group or its derivatives towards nucleophilic attack.An unusual methylation of 3-methyl-5-nitrobenzene-1,2,4-triol to give the (E)-3,6-dihydroxy-2-methyl-1,4-benzoquinone 4-methoxyimine N-oxide is noted.A novel indole formation is described.