65906-40-3Relevant academic research and scientific papers
Uracil derivatives and production thereof
-
, (2008/06/13)
New derivatives of the formula: STR1 (wherein X is O or NH; R1 is --OH which may optionally be etherified or esterified, etherified mercapto or --NH2 which may optionally be substituted; R2 and R3, respectively, mean H, lower alkyl or STR2 and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4-tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions. The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.
