65908-19-2Relevant academic research and scientific papers
Iodine-Mediated Cyclization of Enamines to Imidazole-4-Carboxylic Derivatives with Sequential Removal of Nitrogen Atoms from TMSN3
Gao, Peng,Chen, Huaijuan,Bai, Zi-Jing,Zhang, Sheng,Zhao, Mi-Na,Yang, Desuo,Li, Yingchun,Zhang, Jiangwei,Wang, Xiaomei
, p. 10492 - 10500 (2021)
An iodine-mediated oxidative [4+1] cyclization of enamines with TMSN3 for the synthesis of 2,5-disubstituted imidazole-4-carboxylic derivatives has been developed. The mechanistic studies revealed that the reaction proceeds through a sequential removal of two nitrogen atoms from TMSN3. The synthetic utility was further demonstrated with a gram-scale reaction and various derivatization transformations of the products.
2, 5-substituent-1H-imidazole-4-carboxylic ester compound and synthesis and purification method thereof
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Paragraph 0023-0027, (2021/05/08)
The invention provides a 2, 5-substituent-1H-imidazole-4-carboxylic ester compound and a synthesis and purification method thereof, the method uses iodine as an oxidizing agent to promote the oxidative cyclization reaction of an enamine compound, so that the operation of preparing the 2, 5-substituent-1H-imidazole-4-carboxylic ester compound is simpler, the preparation cost is greatly reduced, the relative yield and purity are higher, and the environmental pollution is less. Besides, the 2, 5-substituent-1H-imidazole-4-carboxylic ester compound provided by the invention has been widely applied in the fields of medicine, ligand chemistry and material science due to the special heterocyclic skeleton, and is a valuable synthetic intermediate and a functional organic molecule.
