65922-92-1

Upstream product

• 60-23-1 Cysteamine 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 2897-03-2 7-phenyl-1,4-thiazepan-5-one 

Downstream Products

• 73920-79-3 6-Chlor-2,3-dihydro-7-phenyl-1,4-thiazepin-5(4H)-on 
• 73920-81-7 6-Brom-2,3-dihydro-7-phenyl-1,4-thiazepin-5(4H)-on 
• 148341-98-4 7-Phenyl-2,3,4,5-tetrahydro-1,4-thiazepine 

Relevant academic research and scientific papers

Substituted thiazepines as central nervous system agents

Substituted thiazepines are described as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic and antidepressant agents as well as for tr

Contributions to the Chlorination-Dehydrochlorination of Perhydro-1,4-thiazepin-5-ones

The synthesis of unsaturated derivatives of perhydro-1,4-thiazepin-5-ones 3 is investigated.Depending on the substitution the thiazepin-5-ones 3 thereby react with sulfuryl chloride to yield 7-and 2-chloro derivatives 6 and 7; the latter eliminate hydrogen chloride only in the presence of a base (PVP, 8) to give the Δ2-thiazepines 9a,b,d,e,g, whereas the 7-chloro derivatives in situ afford the Δ6-thiazepines 10a - f, the 1,4-thiazepinium chloride 11c being isolated as intermediate. tert-Butyl hypochlorite forms according to the substituent size and solvent polarity 2- and 7-halogenation products, as well as 1,4-thiazepin-5-one-S-oxides 22.Further halogenation of the Δ6-1,4-thiazepines 10a - c results in the formation of unsaturated halogen derivatives 24, 25, and 26.