6593-87-9Relevant academic research and scientific papers
Tautomerism in 2-Trichloro- and 2-Trifluoro-acetamidothiazoles
Birkinshaw, Timothy N.,Harkin, Shaun A.,Kaye, Perry T.,Meakins, G. Denis,Smith, Antony K.
, p. 939 - 944 (2007/10/02)
Series of new 4- and 5-substituted thiazoles with acetamido-, mono-, di-and tri-chloroacetamido- , and tri-fluoroacetamido-groups at position 2 have been prepared.Amide-acylimine tautomerism in these compounds has been investigated by comparing their i.r. and u.v. spectra in carbon tetrachloride and in acetonitrile with those of related 2-N-methylacetamido- and 3-methyl-2-acetylimino-thiazoles.The trichloro- and trifluoro-acetamides exhibit tautomerism in both solvents; the acylimino-forms are most stable with the trifluoro-compounds in the more polar solvent.
