65933-95-1Relevant academic research and scientific papers
Regioselective synthesis of 1,4,6-trisubstituted-2-pyridinones and 2,3-disubstituted (2H)-isoquinolin-1-ones via tandem stille reaction/ heterocyclisation
Cherry, Khalil,Duchene, Alain,Thibonnet, Jerome,Parrain, Jean-Luc,Abarbri, Mohamed
, p. 2349 - 2356 (2007/10/03)
A general route to 1,4,6-trisubstituted 2-pyridinones and 2,3-disubstituted (2H)-isoquinolin-1-ones from (Z)-3-iodovinylic amides 1a-h and 2-iodo N-substituted benzamides 2a-f is described, including compounds bearing a substituent on the aromatic ring. Treatment of (Z)-β-iodovinylic amides 1a-h and 2-iodobenzamides 2a-f with various allenyltributyltin reagents in the presence of palladium acetate, triphenylphosphine and tetrabutylammonium bromide in acetonitrile provided good yields of the corresponding 1,4,6-trisubstituted 2-pyridinones 3a-k and 2,3-disubstituted (2H)-isoquinolin-1-ones 4a-i via tandem Stille reaction and 6-endo-dig azacyclisation. Georg Thieme Verlag Stuttgart.
Regio- and selective synthesis of 4,6-disubstituted-2-pyridones
Cherry, Khalil,Abarbri, Mohamed,Parrain, Jean-Luc,Duchêne, Alain
, p. 5791 - 5794 (2007/10/03)
Palladium catalysed regio- and stereoselective annulation of allenyl stannanes by β-iodo vinylic amides gives good yields of the corresponding 2-pyridones. This annulation probably occurs via a Stille reaction/cyclisation sequence.
