65940-18-3Relevant academic research and scientific papers
Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
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, (2008/06/13)
This invention relates to electrophilic dipeptide analogs conjugated to an N,N-disubstituted alpha -amino acid as inhibitors of trypsin-like serine protease enzymes.
Bradykinin receptor antagonists containing N-substituted amino acids: In vitro and in vivo B2 and B1 receptor antagonist activity
Goodfellow, Val S.,Marathe, Manoj V.,Kuhlman, Karen G.,Fitzpatrick, Timothy D.,Cuadrado, David,Hanson, Wendy,Zuzack, John S.,Ross, Sherman E.,Wieczorek, Maciej,Burkard, Michael,Whalley, Eric T.
, p. 1472 - 1484 (2007/10/03)
We report a systematic probing of the structural requirements of the bradykinin (BK) type 2 (B2) receptor for antagonist activity by incorporating N-alkyl-amino acid residues at positions 7 and 8 of a potent antagonist sequence. Compound 1 (D-A
