65941-63-1

Upstream product

• 55444-94-5 dimethyl 2-oxo-3-(p-fluorophenoxy)propanephosphonate 
• 38754-71-1 (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate 

Downstream Products

• 79136-87-1 N-(methanesulfonyl)-16-(p-fluorophenoxy)-ω-tetranor-PGE₂-carboxamide 
• 62408-28-0 (3aR,4R,5R,6aS)-4-[(E)-(R)-4-(4-Fluoro-phenoxy)-3-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-2-one 
• 55444-98-9 (3aR,4R,5R,6aS)-4-[(E)-(R)-4-(4-Fluoro-phenoxy)-3-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-2-ol 
• 55444-97-8 (3aR,4R,5R,6aS)-4-[(E)-(R)-4-(4-Fluoro-phenoxy)-3-hydroxy-but-1-enyl]-5-hydroxy-hexahydro-cyclopenta[b]furan-2-one 
• 71249-17-7 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-[(E)-(S)-4-(4-fluoro-phenoxy)-3-hydroxy-but-1-enyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 71249-17-7 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-[(E)-(R)-4-(4-fluoro-phenoxy)-3-hydroxy-but-1-enyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 

Relevant academic research and scientific papers

N-(Methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissue-Selective, Uterine Stimulants

In an effort to develop tissue-selective prostaglandin analogues resistant to the metabolic inactivating pathways of the natural materials, hybrid compounds modified both at C-1 with a sulfonimide moiety and in the n-amylcarbinol side chain with substituted phenoxy groups were synthesized and evaluated in a variety of in vitro and in vivo models.Several of these analogues exhibited potent, tissue-selective, uterine stimulant activity, a finding subsequently confirmed in clinical studies with one member of this series, N-(methanesulfonyl)-16-phenoxy-ω-tetranor-PGE2-carboxamide (CP-34089/ZK-57671, sulprostone).