65963-23-7Relevant academic research and scientific papers
Development of the carboxamide protecting group, 4-(tert -butyldimethylsiloxy)-2-methoxybenzyl
Muranaka, Kazuhiro,Ichikawa, Satoshi,Matsuda, Akira
supporting information; experimental part, p. 9278 - 9293 (2012/01/04)
The new carboxamide protecting group, 4-(tert-butyldimethylsiloxy)-2- methoxybenzyl (SiMB), has been developed. While this SiMB group can be removed using mild basic desilylation methods, it can also be deprotected under strongly acidic or oxidative conditions. An application of this group to simple carboxamide groups, as well as to more complex and acid-sensitive adenosine derivatives containing a cyclophane scaffold, was also demonstrated.
