65966-04-3

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 51135-56-9 1-amino-4-methylpyridin-1-ium 2,4,6-trimethylbenzene sulfonate 
• 1606181-79-6 4-methoxy-N-(4-methylpyridin-2-yl)benzimidamide 

Relevant academic research and scientific papers

PhI(OCOCF3)2-mediated intramolecular oxidative N-N bond formation: Metal-free synthesis of 1,2,4-triazolo[1,5-a]pyridines

The biologically important 1,2,4-triazolo[1,5-a]pyridines were readily synthesized from N-(pyridin-2-yl)benzimidamides via phenyliodine bis(trifluoroacetate)-mediated intramolecular annulation. This novel strategy allows for the convenient construction of a 1,2,4-triazolo[1,5-a]pyridine skeleton through direct metal-free oxidative N-N bond formation, featuring a short reaction time and high reaction yields.

Non-steroidal pregnancy-terminating agents: Design, synthesis and structure-activity relationships of 2-aryl-1,2,4-triazolo[1,5-a]pyridine

The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111 - a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration.