65966-05-4

Upstream product

• 2920-38-9 4-cyano-1,1'-biphenyl 
• 51135-56-9 1-amino-4-methylpyridin-1-ium 2,4,6-trimethylbenzene sulfonate 

Downstream Products

• 65964-69-4 2-biphenyl-4-yl-7-(2-dibenzofuran-3-yl-vinyl)-[1,2,4]triazolo[1,5-a]pyridine 
• 65964-75-2 7-(4-benzofuran-2-yl-styryl)-2-biphenyl-4-yl-[1,2,4]triazolo[1,5-a]pyridine 
• 65964-72-9 2-biphenyl-4-yl-7-[2-(2-phenyl-benzofuran-6-yl)-vinyl]-[1,2,4]triazolo[1,5-a]pyridine 

Relevant academic research and scientific papers

Non-steroidal pregnancy-terminating agents: Design, synthesis and structure-activity relationships of 2-aryl-1,2,4-triazolo[1,5-a]pyridine

The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111 - a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration.