65966-19-0Relevant academic research and scientific papers
Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines
Moszczyński-P?tkowski, Rafa?,Majer, Jakub,Borkowska, Ma?gorzata,Bojarski, ?ukasz,Janowska, Sylwia,Mat?oka, Miko?aj,Stefaniak, Filip,Smuga, Damian,Bazyd?o, Katarzyna,Dubiel, Krzysztof,Wieczorek, Maciej
, p. 96 - 116 (2018)
New compounds containing [1,2,4]triazolo [1,5-a]pyridine (I), pyrazolo [1,5-a]pyridine (II), 1H-1,3-benzodiazole (III) and imidazo [1,2-a]pyrimidine (IV) backbones were designed and synthesized for PDE10A interaction. Among these compounds, 1H-1,3-benzodiazoles and imidazo [1,2-a]pyrimidines showed the highest affinity for PDE10A enzyme as well as good metabolic stability. Both classes of compounds were identified as selective and potent PDE10A enzyme inhibitors.
