6597-25-7Relevant academic research and scientific papers
Synthesis and antiplasmodial activity of new indolone N-Oxide derivatives
Nepveu, Fran?oise,Kim, Sothea,Boyer, Jeremie,Chatriant, Olivier,Ibrahim, Hany,Reybier, Karine,Monje, Marie-Carmen,Chevalley, Severine,Perio, Pierre,Lajoie, Barbora H.,Bouajila, Jalloul,Deharo, Eric,Sauvain, Michel,Tahar, Rachida,Basco, Leonardo,Pantaleo, Antonella,Turini, Francesco,Arese, Paolo,Valentin, Alexis,Thompson, Eloise,Vivas, Livia,Petit, Serge,Nallet, Jean-Pierre
experimental part, p. 699 - 714 (2010/07/09)
A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), aswell as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound 26 (5-methoxy-indolone-N-oxide analogue) had the most potent antiplasmodial activity in vitro (50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound 1 (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitaemia at 30 mg/kg/day. 2009 American Chemical Society.
A combined experimental and density functional theory study on the Pd-mediated cycloisomerization of o-alkynylnitrobenzenes - Synthesis of isatogens and their evaluation as modulators of ROS-mediated cell death
Ramana, Chepuri V.,Patel, Pitambar,Vanka, Kumar,Miao, Benchun,Degterev, Alexei
, p. 5955 - 5966 (2011/03/17)
Highly selective cycloisomerization of o-alkynylnitrobenzenes, leading to isatogens, has been achieved by employment of a PdII complex. This reaction is very general and functional-group-tolerant. The possible mechanism of this reaction was inv
Enamines: Part III - A New Synthesis of Substituted 2-Arylisatogens and o-Nitrophenyl Benzyl Ketones
Bhamare, N. K.,Kamath, H. V.,Kulkarni, Sheshgiri N.
, p. 613 - 615 (2007/10/02)
Condensation of substituted o-nitrobenzoyl chloride with o/p-nitro substituted β-morpholinostyrenes gives α-acyl-β-morpholinostyrenes which are converted into the title compounds.
