659729-80-3

Basic information

• Product Name: 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI);3-AMINO-8-HYDROXYQUINOXALIN-2(1H)-ONE;2(1H)-Quinoxalinone, 3-aMino-8-hydroxy-
• CAS NO: 659729-80-3
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Product Categories: PIPERIDINE
• Mol File: 659729-80-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.686g/cm³
• Refractive Index: 1.779
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI)(659729-80-3)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI)(659729-80-3)

Safety Data

• Hazardous Substances Data: 659729-80-3(Hazardous Substances Data)

Usage

General Description

2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI) is a chemical compound with the molecular formula C8H7N3O2. It is a heterocyclic compound with a quinoxaline ring structure, containing both an amino group and a hydroxy group. 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI) has potential pharmaceutical applications, including as a building block for the synthesis of various bioactive molecules. It may also have biological activities such as antioxidant and anti-inflammatory properties. Further research and investigation into the potential uses and properties of 2(1H)-Quinoxalinone,3-amino-8-hydroxy-(9CI) may lead to its development as a valuable drug or therapeutic agent.

InChI:InChI=1/C8H7N3O2/c9-7-8(13)11-6-4(10-7)2-1-3-5(6)12/h1-3,12H,(H2,9,10)(H,11,13)

Upstream product

• 659729-78-9 3-amino-8-methoxy-1H-quinoxalin-2-one 

Relevant articles and documents

Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate

A series of novel 4-oxopyrimidine TRPV1 antagonists was evaluated in assays measuring the blockade of capsaicin or acid-induced influx of calcium into CHO cells expressing TRPV1. The investigation of the structure-activity relationships in the heterocyclic A-region revealed the optimum pharmacophoric elements required for activity in this series and resulted in the identification of subnanomolar TRPV1 antagonists. The most potent of these antagonists were thoroughly profiled in pharmacokinetic assays. Optimization of the heterocyclic A-region led to the design and synthesis of 23, a compound that potently blocked multiple modes of TRPV1 activation. Compound 23 was shown to be effective in a rodent "on-target" biochemical challenge model (capsaicin-induced flinch, ED50 = 0.33 mg/kg p.o.) and was antihyperalgesic in a model of inflammatory pain (CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg, p.o.). Based on its in vivo efficacy and pharmacokinetic profile, compound 23 (N-{4-[6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl} -acetamide; AMG 517) was selected for further evaluation in human clinical trials.