659743-39-2Relevant academic research and scientific papers
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors
Patman, Joanne,Bhardwaj, Namrta,Ramnauth, Jailall,Annedi, Subhash C.,Renton, Paul,Maddaford, Shawn P.,Rakhit, Suman,Andrews, John S.
, p. 2540 - 2544 (2008/02/01)
A series of substituted 2-aminobenzothiazole compounds have been synthesized and evaluated as nitric oxide synthase (NOS) inhibitors. Compound 14 shows activity in the nM range and is selective for the human neuronal NOS isoform. We have also evaluated the compounds against the rat NOS isoforms. For some of the compounds, there are significant differences in NOS inhibitory activities between the human and rat enzymes. For example, compound 10b has nM activity against the rat nNOS while low μM activity against the human nNOS.
AMINO BENZOTHIAZOLE COMPOUNDS WITH NOS INHIBITORY ACTIVITY
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Page 45-46, (2008/06/13)
The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating s
