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659747-53-2

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659747-53-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 659747-53-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,9,7,4 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 659747-53:
(8*6)+(7*5)+(6*9)+(5*7)+(4*4)+(3*7)+(2*5)+(1*3)=222
222 % 10 = 2
So 659747-53-2 is a valid CAS Registry Number.

659747-53-2Downstream Products

659747-53-2Relevant articles and documents

Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-Thiazolylquinazolines

Gaul, Micheal D.,Guo, Yu,Affleck, Karen,Cockerill, G. Stuart,Gilmer, Tona M.,Griffin, Robert J.,Guntrip, Stephen,Keith, Barry R.,Knight, Wilson B.,Mullin, Robert J.,Murray, Doris M.,Rusnak, David W.,Smith, Kathryn,Tadepalli, Sarva,Wood, Edgar R.,Lackey, Karen

, p. 637 - 640 (2007/10/03)

We have identified a novel class of 6-thiazolylquinazolines as potent and selective inhibitors of both ErbB-2 and EGFR tyrosine kinase activity, with IC50 values in the nanomolar range. These compounds inhibited the growth of both EGFR (HN5) and ErbB-2 (BT474) over-expressing human tumor cell lines in vitro. Using xenograft models of the same cell lines, we found that the compounds given orally inhibited in vivo tumor growth significantly compared with control animals.

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