65976-63-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE is used as a building block for the synthesis of pharmaceutical compounds, leveraging its unique structure to contribute to the development of new drugs. Its potential pharmacological activities make it a valuable component in the formulation of medications aimed at treating various health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE is utilized as an intermediate in the production of pesticides. Its incorporation into these products is driven by its capacity to enhance the effectiveness of pest control solutions, thereby supporting agricultural productivity and crop protection.
Used in Research and Development:
4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE is employed as a research compound for exploring its potential biological activities. Scientists and researchers use 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE to investigate its interactions with biological systems, which can lead to a better understanding of its mechanisms of action and potential applications in medicine and agriculture.

Upstream product

• 110-91-8 morpholine 
• 611-06-3 2,4-dichloronitrobenzene 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 65976-56-9 2,2'-(5-chloro-2-nitro-phenylazanediyl)-bis-ethanol 

Downstream Products

• 133387-34-5 4-[3-(morpholin-4-yl)-4-nitrophenyl]morpholine 
• 294649-44-8 4-[5-(4-Methyl-piperazin-1-yl)-2-nitro-phenyl]-morpholine 

Relevant academic research and scientific papers

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC50 = 0.0008 μM) served as a proof-of-concept candidate in a collagen-induced model of arthri

AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE

The invention relates to compounds of Formula (I), wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.

Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene

Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclooctane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.