65976-78-5

Upstream product

• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 52344-93-1 methyl 2-formyl-3,5-dimethoxybenzoate 
• 16849-78-8 2-formyl-3,5-dihydroxybenzoic acid methyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 116502-80-8 3-hydroxy-5-methoxy-1,2-benzenedimethanol 
• 83025-47-2 3-Hydroxy-5-methoxy-4-((4aR,8aR)-2,5,5,8a-tetramethyl-3,4,4a,5,8,8a-hexahydro-naphthalen-1-ylmethyl)-benzene-1,2-dicarbaldehyde 
• 1275617-33-8 allyl 2-{(R)-2-[3-(allyloxycarbonylaminomethyl)-1,2,4-oxadiazol-5-yl]-2-[2-(2-hydroxyacetylamino)acetylamino]ethylsulfanylmethyl}-6-bromo-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate 
• 1275617-46-3 6-bromo-3-[dimethyl(thexyl)silyloxy]-2-[(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-5-methoxybenzoic acid 
• 1275617-30-5 allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate 
• 1275617-09-8 allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-chloro-5-methoxybenzoate 
• 1275617-07-6 allyl 2-[(R)-2-amino-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-6-chloro-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate 
• 1275616-84-6 allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-formyl-3-methoxybenzoate 
• 1275616-81-3 allyl 2-bromo-6-formyl-5-hydroxy-3-methoxybenzoate 
• 1275617-13-4 (7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-11-thioxo-9,10,11,12,13,14-hexahydro-16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8-dione 
• 1275617-12-3 (7R,13R)-4-bromo-1-hydroxy-3-methoxy-13-(3-methyl-1,2,4-oxadiazol-5-yl)-7-phenyl-9,10,13,14-tetrahydro-12H,16H-6-oxa-15-thia-9,12-diazabenzocyclotetradecene-5,8,11-trione 
• 1275616-76-6 methyl 2-chloro-6-formyl-5-hydroxy-3-methoxybenzoate 

Relevant academic research and scientific papers

Convergent total synthesis of corallocin A

The first total synthesis of corallocin A is described herein. The Suzuki coupling reaction as a key step proceeded with high stereoselectivity and in good yield. Robust transformations, including Vilsmeier-Haack formylation and Wittig reaction, allowed for effective access to corallocin A.

SMTP GROUP OR SMTP-7 PRODUCTION INTERMEDIATE AND CHEMICAL PRODUCTION METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a compound having a dihydropyran structure that can be a useful intermediate in chemically producing a group of Pre-SMTP, SMTP. SOLUTION: The present invention provides a compound having a dihydropyran structure represente

CHEMICAL METHOD OF PRODUCING SMTP GROUPS OR SMTP-7 AND INTERMEDIATES USED IN THE METHOD

The present invention provides a compound having a dihydropyran structure, a method of producing a compound having a dihydropyran structure, a method of producing Pre-SMTP, a method of producing a group of SMTPs, and a pharmaceutical composition. The comp

Aminopyrimidine compound

The invention discloses an aminopyrimidine compound. The structural general formula of the compounds is shown as a formula I in the specification. In the formula I, R1 is one of alkyl with a carbon atom total number of 1-6, cycloalkyl with a carbon atom total number of 3-6, halogen substituted alkyl with a carbon atom total number of 1-6 and halogen substituted cycloalkyl with a carbon atom totalnumber of 3-6, R2 is alkoxy with a carbon atom total number of 1-6, halogen substituted alkoxy with a carbon atom total number of 1-6, cycloalkyl with a carbon atom total number of 3-6 and halogen substituted cycloalkyl with a carbon atom total number of 3-6, and X is F, Br or Cl. The compound has a remarkable antibacterial effect and a good drug forming property.

Synthesis of novel resveratrol-phthalide hybrid compounds and evaluation of their inhibitory activities of nitric oxide production

Four types of novel resveratrol-phthalide hybrid compounds were designed and synthesized systematically by Suzuki-Miyaura cross-coupling reaction. These hybrid compounds were evaluated upon an inhibitory effect of the LPS-stimulated NO production in murine macrophage cell line, RAW264.7. As a result, two of them showed stronger inhibitory activity than the original resveratrol.

1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF

A 1-amino-phthalazine derivative of general formula (I) wherein the substituents are as defined herein. Also disclosed are a method for preparing such compounds, intermediates for use in such method and medical treatments using the compounds of formula (I