65977-55-1

Usage

Uses

Used in Organic Synthesis:
5-Chlorothieno[3,2-b]pyridine is used as a building block for the creation of more complex chemical compounds. Its unique structure allows for the synthesis of a wide range of molecules, making it a valuable component in the field of organic chemistry.
Used in Pharmaceutical Industry:
5-Chlorothieno[3,2-b]pyridine is used as a precursor in the preparation of various drug molecules. Its potential applications in medicine are still being explored, but its presence in the synthesis of pharmaceutical compounds highlights its importance in the development of new therapeutic agents.

Upstream product

• 34898-65-2 thieno<3,2-b>pyridine 4-oxide monohydrate 

Downstream Products

• 912332-40-2 3-bromo-5-chlorothieno[3,2-B]pyridine 
• 1338369-15-5 C₁₆H₁₃NO₃S 
• 1093631-51-6 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid 
• 1093631-80-1 ethyl 5-{4-[(phenylmethyl)oxy]phenyl}thieno[3,2-b]pyridine-2-carboxylate 
• 1093631-81-2 C₂₀H₁₅NOS 

Relevant academic research and scientific papers

Chemistry of Thienopyridines. XXXIII. Synthetic Routes to 5- and 7-Substituted Thienopyridines from the N-Oxide

Thienopyridine (1) is oxidized to N-oxide 1a by means of m-chloroperoxybenzoic acid (83percent).Compound 1a forms adducts with hydrogen chloride and picric acid and gives ring substitution alpha or gamma to the heteronitrogen atom.Thus, 1a plus nitric and sulfuric acids produces the 7-nitro-N-oxide 1m (63percent), or plus phosphorus oxychloride gives a mixture of 5-chloro and 7-chloro (1j) derivatives of 1.Compound 1m is convertible into a variety of other derivatives of 1, viz 7-chloro-N-oxide, 1j, 7-bromo-N-oxide, 7-nitro and 7-amino. 5-Cyano-1, formed from 1a, is, in turn, transformed into a methyl imidate (93percent), cyclic amidines, and a 5-tetrazolyl-1 (91percent).These results confirm the prediction that 1a, thienopyridine-4-oxide and quinoline 1-oxide should exhibit closely similar (i.e. analogous) chemical reactions.