65981-50-2

Basic information

• Product Name: (1R,5S)-6,7-dimethyl-6,7-diazabicyclo[3.2.2]non-3-yl 3-hydroxy-2-phenylpropanoate
• CAS NO: 65981-50-2
• Molecular Formula: C₁₈H₂₆N₂O₃
• Molecular Weight: 318.4106
• Mol File: 65981-50-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 464.2°C at 760 mmHg
• Flash Point: 234.5°C
• Density: 1.2g/cm³
• Vapor Pressure: 2.05E-09mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: (1R,5S)-6,7-dimethyl-6,7-diazabicyclo[3.2.2]non-3-yl 3-hydroxy-2-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,5S)-6,7-dimethyl-6,7-diazabicyclo[3.2.2]non-3-yl 3-hydroxy-2-phenylpropanoate(65981-50-2)
• EPA Substance Registry System: (1R,5S)-6,7-dimethyl-6,7-diazabicyclo[3.2.2]non-3-yl 3-hydroxy-2-phenylpropanoate(65981-50-2)

Safety Data

• Hazardous Substances Data: 65981-50-2(Hazardous Substances Data)

Relevant articles and documents

Structure-activity relationship in a new series of atropine analogues. I. N,N'-disubstituted 6,7-diazabicyclo[3,2,2]nonane derivatives

The synthesis of a new series of N,N'-disubstituted 6,7-diazabicyclo[3.2.2]nonane derivatives is described. The antimuscarinic potency of these drugs was evaluated in the guinea pig ileum and compared to that of atropine sulfate. All the drugs tested competitively inhibited the acetylcholine-induced contractions. K(d) values were calculated and, in several cases, compared to those obtained by direct binding to the muscarinic receptor from mouse brain. The order of potencies followed that which is known for various tropine and pseudotropine esters; that is, the 3α configuration is more potent than the 3β configuration, and the quaternary analogues are more potent than the tertiary ones. The antimuscarinic activity of the drugs is discussed in terms of their acetylcholine-like molecular arrangement that gives rise to a characteristic interaction pharmacophore.