65988-71-8

Basic information

• Product Name: GD2-GANGLIOSIDE
• Synonyms: DISIALOGANGLIOSIDE-GD2;DISIALOGANGLIOSIDE GD2, BOVINE;DISIALOGANGLIOSIDE GD2, HUMAN;II3(NEUAC)2-GGOSE3CER;GALNAC-BETA1,4(NEU5ACA-ALPHA2,8)(NEU5AC-ALPHA2,O3)GAL-BETA,4GLC-BETA1,1' CERAMIDE;GALNAC-BETA1,4(NEU5AC-ALPHA2,8)(NEU5AC-ALPHA2,03)GAL-BETA1,1' CERAMIDE, HUMAN;GANGLIOSIDE GD2, DISIALO;GANGLIOSIDE GD2, DISIALO, HUMAN
• CAS NO: 65988-71-8
• Molecular Formula: C74H134N4O32
• Molecular Weight: 1591.86336
• Product Categories: Acidic glycosphingolipids;Cell Signaling and Neuroscience;Gangliosides;GangliosidesGlycan Component Classes;GangliosidesSphingolipids;Glycosphingolipids;Lipids in Cell Signaling
• Mol File: 65988-71-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1539.3 °C at 760 mmHg
• Flash Point: 884.7 °C
• Appearance: /lyophilized powder
• Density: 1.38 g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: GD2-GANGLIOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GD2-GANGLIOSIDE(65988-71-8)
• EPA Substance Registry System: GD2-GANGLIOSIDE(65988-71-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 65988-71-8(Hazardous Substances Data)

Usage

Description

GD2-GANGLIOSIDE, also known as Disialoganglioside-GD2, is a complex carbohydrate molecule derived from bovine brain. It is a type of ganglioside, which is a family of glycosphingolipids that play a crucial role in cell recognition, adhesion, and signal transduction. GD2-GANGLIOSIDE is composed of a ceramide molecule linked to two sialic acid residues and a complex oligosaccharide chain. Its unique structure and biological properties make it a valuable target for various applications in the fields of medicine, diagnostics, and research.

Uses

Used in Diagnostic Applications:
GD2-GANGLIOSIDE is used as a target antigen in the ganglioside-enzyme-linked immunosorbent assay (ELISA). This diagnostic tool is employed to detect and quantify the presence of specific antibodies, such as anti-GD2 antibody (ch14.18), which can be indicative of certain diseases or conditions.
Used in Immunotherapy:
GD2-GANGLIOSIDE is used as a target for immunotherapy, specifically in the development of monoclonal antibodies like ch14.18. These antibodies can recognize and bind to GD2-GANGLIOSIDE, leading to the destruction of cancer cells that express this antigen on their surface. This approach has shown promise in the treatment of neuroblastoma, a type of cancer commonly associated with GD2-GANGLIOSIDE expression.
Used in Research:
GD2-GANGLIOSIDE is used as a control in capture ELISA to test its effect on reactivating autophagy in primary fibroblasts. Autophagy is a cellular process that involves the degradation and recycling of cellular components, and its dysregulation has been implicated in various diseases, including cancer. By using GD2-GANGLIOSIDE as a control, researchers can better understand the role of this molecule in autophagy regulation and its potential implications for disease treatment.
Used in Pharmaceutical Development:
GD2-GANGLIOSIDE is used as a target for the development of novel therapeutic agents. Given its role in cell recognition and signal transduction, modulating the activity of GD2-GANGLIOSIDE or its interacting partners could have therapeutic potential in various diseases, including cancer and neurodegenerative disorders. Researchers are actively exploring the development of small molecules, peptides, and other agents that can target GD2-GANGLIOSIDE or its associated pathways to treat these conditions.

Biochem/physiol Actions

Disialoganglioside GD2 is expressed in neuroblastoma, melanoma and small cell lung cancer. It is an immunotherapeutic target and is also regarded as a tumor-associated antigen. GD2 may favor cell migrationin tumors by promoting cell growth, as well as extracellular matrix component attachment.