65996-16-9

Basic information

• Product Name: Ethyl 2-broMo-5-Methylnicotinate
• Synonyms: Ethyl 2-broMo-5-Methylnicotinate;2-Bromo-5-methyl-nicotinic acid ethyl ester
• CAS NO: 65996-16-9
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.0852
• Mol File: 65996-16-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-broMo-5-Methylnicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-broMo-5-Methylnicotinate(65996-16-9)
• EPA Substance Registry System: Ethyl 2-broMo-5-Methylnicotinate(65996-16-9)

Safety Data

• Hazardous Substances Data: 65996-16-9(Hazardous Substances Data)

Usage

General Description

Ethyl 2-bromo-5-methylnicotinate is a compound that belongs to the class of organic compounds known as pyridinecarboxylic acids. This chemical is a derivative of nicotinic acid and contains a bromine atom and an ethyl ester group attached to the pyridine ring. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential biological and pharmacological activities. Ethyl 2-bromo-5-methylnicotinate is also used as an intermediate in the production of various fine chemicals and is considered to be of low toxicity.

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Relevant articles and documents

SUBSTITUTED NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES

Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: (Ia), (Ib), (Ic), (Id) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R, R1, R2, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.