660-47-9Relevant academic research and scientific papers
A Diels-Alder approach to the enantioselective construction of fluoromethylated stereogenic carbon centers
Shibatomi, Kazutaka,Kobayashi, Fumito,Narayama, Akira,Fujisawa, Ikuhide,Iwasa, Seiji
supporting information; experimental part, p. 413 - 415 (2012/01/05)
Highly enantioselective Diels-Alder reactions of β- fluoromethylacrylates were carried out in the presence of a Lewis acid activated chiral oxazaborolidine catalyst. These reactions yielded fluoromethylated cyclohexenes, including trifluoromethyl-, difluo
Biosynthesis of salinosporamides from α,β-unsaturated fatty acids: Implications for extending polyketide synthase diversity
Liu, Yuan,Hazzard, Christopher,Eustaquio, Alessandra S.,Reynolds, Kevin A.,Moore, Bradley S.
supporting information; scheme or table, p. 10376 - 10377 (2009/12/23)
(Chemical Equation Presented) A new series of coenzyme A-tethered polyketide synthase extender units were discovered in relation to the biosynthesis of the salinosporamide family of anticancer agents from the marine bacterium Salinispora tropica. In vivo and in vitro experiments revealed that the crotonyl-CoA reductase/carboxylase SalG has broad substrate tolerance toward 2-alkenyl-CoAs that give rise to the salinosporamide C-2 substitution pattern.
