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66018-38-0

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66018-38-0 Usage

Description

LL-Z-1640-2 is a cis-enone resorcylic acid lactone that was first reported in 1978 and later rediscovered as an irreversible and highly selective TAK1 inhibitor. TAK1 is a MAPKKK (Mitogen-Activated Protein Kinase Kinase Kinase) involved in the p38 signaling cascade for pro-inflammatory signals such as cytokines. LL-Z-1640-2 has been shown to effectively prevent inflammation in animal models.

Uses

Used in Pharmaceutical Industry:
LL-Z-1640-2 is used as an anti-inflammatory agent for its ability to effectively prevent inflammation in animal models by inhibiting TAK1, a key enzyme in the p38 signaling cascade for pro-inflammatory signals.
Used in Research Applications:
LL-Z-1640-2 is used as a research tool for studying the role of TAK1 in various cellular processes, particularly those related to inflammation and the immune response. Its irreversible and highly selective nature makes it a valuable compound for investigating the molecular mechanisms underlying these processes.

Biological Activity

Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .

Check Digit Verification of cas no

The CAS Registry Mumber 66018-38-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,0,1 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66018-38:
(7*6)+(6*6)+(5*0)+(4*1)+(3*8)+(2*3)+(1*8)=120
120 % 10 = 0
So 66018-38-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4-,7-3-/t11-,15-,18+/m0/s1

66018-38-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (5Z)-7-Oxozeaenol,(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

1.2 Other means of identification

Product number -
Other names Anisomycin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66018-38-0 SDS

66018-38-0Upstream product

66018-38-0Downstream Products

66018-38-0Relevant articles and documents

Antifouling and fungicidal resorcylic acid lactones from the sea anemone-derived fungus cochliobolus lunatus

Liu, Qing-Ai,Shao, Chang-Lun,Gu, Yu-Cheng,Blum, Mathias,Gan, Li-She,Wang, Kai-Ling,Chen, Min,Wang, Chang-Yun

, p. 3183 - 3191 (2014)

Three new 14-membered resorcylic acid lactones, cochliomycins D-F, 1-3, and eight known analogues, 4-11, were isolated from the sea anemone-derived fungus Cochliobolus lunatus. Compounds 1-4 are diastereomers differing from each other by the absolute configurations of the 4′,5′-diol chiral centers. The absolute configurations of 1-4 were established by the CD exciton chirality method and TDDFT ECD calculations. In antifouling assays, 1, 3-6, and 6a exhibited potent antifouling activities against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations, with EC50 values ranging from 1.82 to 22.5 μg/mL. Noticeably, fungicide whole-plant assays indicated that 6 showed excellent activity on the Plasmopara viticola preventative test at 6 ppm and concentration-dependent activity on the Phytophthora infestans preventative application at 200, 60, and 20 ppm. Preliminary structure-activity relationships are also discussed.

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