66023-94-7Relevant academic research and scientific papers
STEREOSELECTIVE PAPAIN-CATALYZED SYNTHESIS OF ALAFOSFALIN
Solodenko, Vladimir A.,Kukhar, Valeri P.
, p. 6917 - 6918 (2007/10/02)
Papain in powdered form efficiently catalyzes alafosfalin synthesis in miscible aqueous-organic solvent involving L-aminophosphonate in peptide bond formation.
Phosphonodipeptides: synthesis and separation of diastereoisomers
Kafarski, Pawel,Lejczak, Barbara,Mastalerz, Przemslaw,Szewczyk, Jerzy,Wasielewski, Czeslaw
, p. 3081 - 3084 (2007/10/02)
Diastereoisomeric mixtures of phosphonodipeptides, prepared from racemic dialkyl 1-aminoalkanephosphonates, were separated by ion-exchange column chromatography.Phosphonodipeptides were found to be much more readily available from dialkyl 1-aminoalkanephosphonates than from the corresponding free acids and the mixed carboxylic-carbonic anhydride method was found to be the most effective one.
STUDIES ON THE SYNTHESIS OF CHEMOTHERAPEUTICS. PART XI. SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF PHOSPHONOPEPTIDES
Kametani, Tetsuji,Kigasawa, Kazuo,Hiiragi, Mineharu,Wakisaka, Kikuo,Haga, Seiji,et al.
, p. 1205 - 1242 (2007/10/02)
A variety of phosphonopeptides, shown in 2 as a general formula, containg natural and/or unnatural amino acids were synthesized, and their in vitro antibacterial activities were examined.N-Protected amino acids were condensed with 1-amino-ethylphosphonic acid or its ester followed by deprotection and hydrolysis to give the requisite phosphonopeptides.Several compounds showed higher levels of activity against certain members of Gram-negative bacteria than those of Alafosfalin (1) as the standard phosphonopeptide.A brief discussion on structure-activity relationships is also described.
