66033-88-3

Upstream product

• 69617-50-1 2-bromo-4-methyl-benzophenone (Z)-oxime 

Downstream Products

• 72093-94-8 3-phenyl-6-[4-(5-phenyl-[1,2,4]oxadiazol-3-yl)-trans-styryl]-benzo[d]isoxazole 
• 69617-10-3 3-phenyl-6-[trans-2-(2-phenyl-benzofuran-6-yl)-vinyl]-benzo[d]isoxazole 
• 69617-02-3 6-(trans-2-biphenyl-4-yl-vinyl)-3-phenyl-benzo[d]isoxazole 
• 69591-93-1 6-(trans-2-naphthalen-1-yl-vinyl)-3-phenyl-benzo[d]isoxazole 
• 69617-05-6 3-phenyl-6-(4-ξ-styryl-trans-styryl)-benzo[d]isoxazole 
• 69616-99-5 6-(trans-2-naphthalen-2-yl-vinyl)-3-phenyl-benzo[d]isoxazole 
• 71944-47-3 6-[4-(2,5-diphenyl-2H-pyrazol-3-yl)-styryl]-3-phenyl-benzo[d]isoxazole 
• 71944-43-9 3-phenyl-6-[4-(1-phenyl-1H-pyrazol-3-yl)-styryl]-benzo[d]isoxazole 
• 71944-39-3 3-phenyl-6-[4-(3-phenyl-pyrazol-1-yl)-styryl]-benzo[d]isoxazole 
• 69591-86-2 3-phenyl-6-trans-styryl-benzo[d]isoxazole 
• 69617-08-9 6-(trans-2-dibenzofuran-3-yl-vinyl)-3-phenyl-benzo[d]isoxazole 

Relevant academic research and scientific papers

A novel method for the highly efficient synthesis of 1,2-benzisoxazoles under neutral conditions using the Ph3P/DDQ system

The use of Ph3P/DDQ offers a novel, neutral and highly efficient method for the efficient conversion of 2-hydroxyaryl aldoximes and ketoximes to 1,2-benzisoxazoles in excellent yields at room temperature.

Triflic anhydride: A mild reagent for highly efficient synthesis of 1,2-benzisoxazoles, isoxazolo, and isothiazolo quinolines without additive or base

The synthetic utility of trifluoromethanesulphonic anhydride (triflic anhydride, TA) without additive or base for the high-yielding synthesis of a wide variety of 1,2-benzisoxazoles from 2-hydroxyaryl aldoximes and ketoximes under mild conditions has been carried out for the first time. As a continuation of our study, syntheses of isoxazolo and isothiazolo quinolones have also been demonstrated using triflic anhydride under similar conditions. This method is simple and has benefits from the easy way to isolate the products in excellent yields.