66033-90-7

Upstream product

• 31301-41-4 4-nitro-3-phenylisoxazole 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 99934-18-6 ethyl 4-nitro-3-phenylizoxazole-5-carboxylate 
• 124287-00-9 (3aSR,7aRS)-7a-benzoyl-5,6-dimethyl-3a-nitro-3-phenyl-3a,4,7,7a-tetrahydro-1,2-benzisoxazole 
• 124286-99-3 (3aSR,7aRS)-5,6-dimethyl-3a-nitro-3-phenyl-3a,4,7,7a-tetrahydro-1,2-benzisoxazole-7a-carboxylate 
• 108735-45-1 4,7-dihydro-5,6-dimethyl-3-phenyl-1,2-benzisoxazole 

Relevant academic research and scientific papers

Cycloaddition Reactions of 4-Nitro-3-phenylisoxazole with Carbo- and Heterodienes

The title compound 4 reacted as a dienophile with open-chain and cyclic carbodienes as well as the 1-azadiene 16, to yield different polynuclear isoxazole systems.On the contrary, it gave rise preferentially to a Michael-type reaction with the dimethyluracil derivative 19 affording the cine-substitution product 23, whose structure was determined by an X-ray analysis.Some mechanistic features and synthetic opportunities are emphasized.

New Features of Isoxazole Chemistry. The Reaction of Ethyl 4-Nitro-3-phenylisoxazole-5-carboxylate with 2,3-Dimethylbuta-1,3-diene

The title compound (2) was found to undergo a (2 + 4) cycloaddition with 2,3-dimethylbuta-1,3-diene affording the tetrahydro-1,2-benzisoxazole (3), which could be easily converted into the corresponding dihydro derivative (4) by elimination of the NO2 and