660411-95-0

Basic information

• Product Name: 5-Amino-1H-indazole-3-carboxylic acid methyl ester
• Synonyms: 1H-Indazole-3-carboxylicacid,5-amino-,methylester(9CI);1H-Indazole-3-carboxylic acid, 5-amino-, methyl ester;5-Amino-1H-indazole-3-carboxylic acid methyl ester
• CAS NO: 660411-95-0
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.19
• Product Categories: AMINOACID
• Mol File: 660411-95-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 432.24 °C at 760 mmHg
• Flash Point: 215.211 °C
• Appearance: /
• Density: 1.413
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.706
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.45±0.40(Predicted)
• CAS DataBase Reference: 5-Amino-1H-indazole-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1H-indazole-3-carboxylic acid methyl ester(660411-95-0)
• EPA Substance Registry System: 5-Amino-1H-indazole-3-carboxylic acid methyl ester(660411-95-0)

Safety Data

• Hazardous Substances Data: 660411-95-0(Hazardous Substances Data)

Usage

General Description

5-Amino-1H-indazole-3-carboxylic acid methyl ester is a chemical compound with the molecular formula C9H9N3O2. It is a methyl ester derivative of 5-aminoindazole-3-carboxylic acid, which is a heterocyclic compound with potential antineoplastic and anti-inflammatory activities. The methyl ester form of this compound may have similar properties, including potential anti-cancer and anti-inflammatory effects. It is a synthetic chemical compound that is not naturally occurring and is primarily used in laboratory research and development. Its precise mechanism of action and potential applications in medicine and pharmaceuticals are still being studied and evaluated.

InChI:InChI=1/C9H9N3O2/c1-14-9(13)8-6-4-5(10)2-3-7(6)11-12-8/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 1360893-27-1 7-nitro-1H-indazole-3-carboxylic acid methyl ester 
• 78155-75-6 methyl 5-nitro-1H-indazole-3-carboxylate 

Downstream Products

• 1574357-71-3 5-((4-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)-1H-indazole-3-carboxamide 
• 1574358-94-3 5-((4-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-1H-indazole-3-carboxylic acid 
• 1574358-59-0 methyl 5-((4-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-1H-indazole-3-carboxylate 

Relevant articles and documents

1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS

The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.