660424-68-0Relevant academic research and scientific papers
A pyridazine series of α2/α3 subtype selective GABAA agonists for the treatment of anxiety
Lewis, Richard T.,Blackaby, Wesley P.,Blackburn, Timothy,Jennings, Andrew S. R.,Pike, Andrew,Wilson, Rowan A.,Hallett, David J.,Cook, Susan M.,Ferris, Pushpinder,Marshall, George R.,Reynolds, David S.,Sheppard, Wayne F. A.,Smith, Alison J.,Sohal, Bindi,Stanley, Joanna,Tye, Spencer J.,Wafford, Keith A.,Atack, John R.
, p. 2600 - 2610 (2007/10/03)
The development of a series of GABAA α2/α3 subtype selective pyridazine based benzodiazepine site agonists as anxiolytic agents with reduced sedative/ataxic potential is described, including the discovery of 16, a remarkably α3-selective compou
PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
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Page 74, (2008/06/13)
A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevent
