660432-43-9

Basic information

• Product Name: (2-fluoro-4-nitrophenyl)methanol
• Synonyms: (2-fluoro-4-nitrophenyl)methanol;2-Fluoro-4-nitrobenzyl alcohol, 97%;2-Fluoro-4-nitrobenzyl alcohol 97%;3-Fluoro-4-(hydroxymethyl)nitrobenzene, (2-Fluoro-4-nitrophenyl)methanol;2-Fluoro-4-nitrobenzylalcohol97%
• CAS NO: 660432-43-9
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171
• Mol File: 660432-43-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 103-105℃
• Boiling Point: 319.9 °C at 760 mmHg
• Flash Point: 147.3 °C
• Appearance: White to yellow/Solid
• Density: 1.434 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.14±0.10(Predicted)
• CAS DataBase Reference: (2-fluoro-4-nitrophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-fluoro-4-nitrophenyl)methanol(660432-43-9)
• EPA Substance Registry System: (2-fluoro-4-nitrophenyl)methanol(660432-43-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 660432-43-9(Hazardous Substances Data)

Usage

General Description

(2-fluoro-4-nitrophenyl)methanol is a chemical compound with the molecular formula C7H6FNO3. It is a colorless to pale yellow liquid with a molecular weight of 169.13 g/mol. (2-fluoro-4-nitrophenyl)methanol is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized as a reagent in organic chemistry for the preparation of other compounds. Additionally, (2-fluoro-4-nitrophenyl)methanol has been studied for its potential biological and pharmacological properties, making it a valuable tool in drug discovery and development. However, it is important to handle this compound with caution as it may pose harmful effects if not used properly.

Upstream product

• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 157701-72-9 4-nitro-2-fluorobenzaldehyde 
• 392-09-6 2-fluoro-4-nitro-benzoic acid methyl ester 

Downstream Products

• 1057344-36-1 2',3'-O-isopropylidene-uridine 5'-monophosphate (2-fluoro-4-nitrobenzyl)ester 
• 1225287-23-9 2-fluoro-4-nitrobenzyl phosphoramide mustard 
• 1402581-51-4 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea 
• 1402581-52-5 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methoxyethoxymethyl)phenyl]urea 
• 1402581-53-6 1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea 
• 1402581-54-7 1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea 
• 1402581-55-8 1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea 
• 1402581-58-1 N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(2-hydroxyethyl)phenyl]propionamide 
• 840501-15-7 (4-amino-2-fluorophenyl)methanol 
• 1402585-33-4 phenyl (3-fluoro-4-(hydroxymethyl)phenyl)carbamate 
• 1402585-34-5 C₁₃H₁₂F₄N₄O₂ 
• 1402585-75-4 2-fluoro-1-((2-methoxyethoxy)methyl)-4-nitrobenzene 
• 127349-56-8 1-(bromomethyl)-2-fluoro-4-nitrobenzene 
• 1402585-72-1 2-(2-fluoro-4-nitrobenzyloxy)ethanol 

Relevant articles and documents

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR+. The cellular activity of the NTR was proven with a new luminescent NTR probe. We synthesised a diverse set of nitroaromatic prodrugs that by design do not affect LSD1 and are reduced by the NTR to release an active LSD1 inhibitor. The emerging side products were differentially analysed using negative controls, thereby revealing cytotoxic effects. The 2-nitroimidazolyl prodrug of a potent LSD1 inhibitor emerged as one of the best prodrug candidates with a pronounced selectivity window between wild-type and transfected THP1 cells. Our prodrugs are selectively activated and release the LSD1 inhibitor locally, proving their suitability for future targeting approaches.

A piperazine-containing aminopyrimidine derivative and its application

The present invention discloses a piperazine-containing aminopyrimidine derivative having a general formula I. structure, which belongs to kinase CDK4, CDK6 and / or CDK9 inhibitors, can be more widely used in the treatment of a variety of cancers, has gr

Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic

Paradoxically, some TRPV1 agonists are, at the organismal level, both nonpungent and clinically useful as topical analgesics. Here, we describe the scaled-up synthesis and characterization in mouse models of a novel, nonpungent vanilloid. Potent analgesic activity was observed in models of neuropathic pain, and the compound blocked capsaicin induced allodynia, showing dermal accumulation with little transdermal absorption. Finally, it displayed much weaker systemic toxicity compared to capsaicin and was negative in assays of genotoxicity.