660440-45-9Relevant academic research and scientific papers
Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists
Witherington, Jason,Blaney, Emma L.,Bordas, Vincent,Elliott, Richard L.,Gaiba, Alessandra,Garton, Neil,Green, Philip M.,Naylor, Antoinette,Smith, David G.,Spalding, David J.,Takle, Andrew K.,Ward, Robert W.
, p. 5538 - 5541 (2007/10/03)
A series of pyridone-N-benzyl-propanoic acids have been optimised to afford potent orally bioavailable VLA-4 antagonists.
ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES
-
Page/Page column 23, (2010/02/13)
The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.
NOVEL COMPOUNDS
-
Page 26-27, (2010/02/06)
The present invention relates to novel pyridone derivatives capable of inhibiting a4 integrin medicated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by t
