66066-39-5Relevant academic research and scientific papers
Preparation of 5-Cyano-4,6-dimethyl-2H-pyran-2-one and 3-Cyano-5-methoxy-4- methyl-5H-furan-2-one via a one-pot, domino-knoevenagel process
Dawadi, Prativa B. S.,Lugtenburg, Johan
, p. 2539 - 2546 (2010)
5-Cyano-4,6-dimethyl-2H-pyran-2-one (1) has been prepared via a simple one-pot domino-Knoevenagel reaction starting from ethyl acetoacetate (2) and cyanoacetone (3). Similarly, a new racemic 3-cyano-5-methoxy-4-methyl-5H-furan- 2-one (7) has been prepared from 1,1-dimethoxyacetone (6) and cyanoacetic acid (4). The new alkylidene derivatives (Z/E)-ethyl-4-cyano-3-methylbut-3-enoate (5), (Z/E)-ethyl 5-amino-4-cyano-3-methyl-5-oxopent-3-enoate (9), and (2,2-dimethoxy-1-methylethylidene)malononitrile (11) have been prepared via the Knoevenagel reactions. The easy access to these new compounds in good yields shows that ammonium acetate/acetic acid-catalyzed Knoevenagel reactions and domino-Knoevenagel reactions have a broad scope of application. Taylor & Francis Group, LLC.
Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors
Meng, Zhaoyang,Kulkarni, Bheemashankar A.,Kerekes, Angela D.,Mandal, Amit K.,Esposite, Sara J.,Belanger, David B.,Reddy, Panduranga Adulla,Basso, Andrea D.,Tevar, Seema,Gray, Kimberly,Jones, Jennifer,Smith, Elizabeth B.,Doll, Ronald J.,Siddiqui, M. Arshad
scheme or table, p. 592 - 598 (2011/02/26)
Our continued effort toward the development of the imidazo[1,2-a]pyrazine scaffold as Aurora kinase inhibitors is described. Bioisosteric approach was applied to optimize the 8-position of the core. Several new potent Aurora A/B dual inhibitors, such as 25k and 25l, were identified.
Synthesis of thieno[2,3-d]-1,3-dithiol-2-thiones from thieno[2,3-d]-1,2,3- thiadiazoles: Matryoshka-type autoclave for high-temperature, high-pressure thermolysis microscale reactions
Jordis, Ulrich,Bhattacharya, Kaberi,Boamah, Philip Y.,Lee, Ving J.
, p. 145 - 154 (2007/10/03)
Thieno[2,3-d]-1,2,3-thiadiazoles (1) react with carbon disulfide in a "Matryoshka-type" double compartment autoclave [1] to yield thieno[2,3-d]-1,3-dithiol-2-thiones (2). With BH3/Me2S the cyclic trithiocarbonate (2d) is cleaved and the product characterized after methylation as 4b. Compounds 7a and 7b are prepared via the thieno[2,3-d]-1,3- dithiolium salts (6) followed by NaBH4-reduction.
