660844-94-0 Usage
Molecular weight
286.74 g/mol The relative molecular mass of 1-Pyrrolidinecarboxylic acid, 3-(4-chlorophenyl)-3-(2-oxoethyl)-, ethyl
ester is 286.74 grams per mole.
Structure
The compound has a pyrrolidine ring with a carboxyl group (-COOH) attached to it. A 4-chlorophenyl group is attached to the 3-position of the pyrrolidine ring, and a 2-oxoethyl group is attached to the same position as the carboxyl group. An ethyl ester group (-OCH2CH3) is present at the carboxyl group.
Appearance
The compound is typically a pale yellow solid or oily liquid.
Solubility
It is soluble in common organic solvents such as ethanol, methanol, and acetone, but has low solubility in water.
Stability
The compound is stable under normal temperature and pressure conditions. However, it may decompose upon exposure to high temperatures or strong oxidizing agents.
Reactivity
The compound can undergo various chemical reactions, such as ester hydrolysis, amide formation, and nucleophilic substitution, due to the presence of functional groups like the carboxyl group, 2-oxoethyl group, and ethyl ester group.
Applications
1-Pyrrolidinecarboxylic acid, 3-(4-chlorophenyl)-3-(2-oxoethyl)-, ethyl
ester is widely used in the pharmaceutical and agricultural industries as a building block for the synthesis of various drugs and crop protection agents. It is also used as a research chemical in the development of new compounds with potential therapeutic and agricultural uses.
Synthesis
The compound is derived from 3-(4-chlorophenyl)pyrrolidine-3-carboxylic acid, which is a key intermediate in the synthesis of pharmaceutical and agricultural chemicals. The ethyl ester derivative is formed by reacting the parent carboxylic acid with ethanol in the presence of an acid catalyst.
Check Digit Verification of cas no
The CAS Registry Mumber 660844-94-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,0,8,4 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 660844-94:
(8*6)+(7*6)+(6*0)+(5*8)+(4*4)+(3*4)+(2*9)+(1*4)=180
180 % 10 = 0
So 660844-94-0 is a valid CAS Registry Number.
660844-94-0Relevant academic research and scientific papers
Design, Synthesis, and Evaluation of Metabolism-Based Analogues of Haloperidol Incapable of Forming MPP+-like Species
Lyles-Eggleston,Altundas,Xia,Sikazwe,Fan,Yang,Li,Zhang,Zhu,Schmidt,Vanase-Frawley,Shrihkande,Villalobos,Borne,Ablordeppey
, p. 497 - 508 (2007/10/03)
The long-term, irreversible, Parkinsonism-like side effects of haloperidol have been speculated to involve several mechanisms. More recently, it has been speculated that the metabolic transformation to MPP+-like species may contribute to the Parkinsonism-like side effects. Because BCPP+ and its reduced analogue have been shown to possess the potential to destroy dopamine receptors in the nigrostriatum, we have designed new analogues of haloperidol lacking the structural features necessary to form neurotoxic quaternary species but retaining their dopamine-binding capacity. The most potent agent at the D2 receptor, the homopiperidine analogue 11, was found to be equipotent to haloperidol. It was also of interest to identify analogues with DA binding profiles similar to that of clozapine at the dopamine receptor subtypes. Evaluation of the proposed agents shows that the ratio of D2 to D4 (2) binding of clozapine was mimicked by 7 [Ki(D2) = 33, Ki(D3) = 200, Ki(D4) = 11 nM; Ki(D2)/Ki(D4) = 3] and 9 [Ki(D2) = 44, Ki(D3) = 170, Ki(D4) = 24 nM; Ki(D2)/Ki(D4) = 2]. A preliminary in-vivo testing of compound 7 shows that its behavioral profile is similar to that of clozapine. This profile suggests that there is a need for further evaluation of these two synthetic agents and their enantiomers for efficacy and lack of catalepsy in animal models.
