AC-ARG-GLY-LYS(AC)-AMC is a novel fluorogenic substrate used for assessing histone deacetylase (HDAC) activity. It is a synthetic peptide that, upon deacetylation by HDACs, releases the fluorescent molecule 7-amino-4-methylcoumarin (AMC), allowing for the quantification of enzyme activity. This substrate is particularly useful in biological and medicinal research for studying the function and inhibition of HDACs, which play a crucial role in the regulation of gene expression and are implicated in various diseases.
660846-97-9
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Basic information
- Product Name: AC-ARG-GLY-LYS(AC)-AMC
- Synonyms: AC-ARG-GLY-LYS(AC)-AMC;N2-Acetyl-L-arginylglycyl-N3-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide trifluoroacetate salt;N-Acetyl-Arg-Gly-Lys(acetyl)-7-amido-4-methylcoumarin trifluoroacetate salt;Ac-Arg-Gly-Lys(Ac)-AMC trifluoroacetate salt
- CAS NO:660846-97-9
- Molecular Formula: C28H40N8O7
- Molecular Weight: 600.67
- EINECS: N/A
- Product Categories: N/A
- Mol File: 660846-97-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: ?20°C
- Solubility: N/A
- CAS DataBase Reference: AC-ARG-GLY-LYS(AC)-AMC(CAS DataBase Reference)
- NIST Chemistry Reference: AC-ARG-GLY-LYS(AC)-AMC(660846-97-9)
- EPA Substance Registry System: AC-ARG-GLY-LYS(AC)-AMC(660846-97-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 660846-97-9(Hazardous Substances Data)
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660846-97-9 Usage
Uses
Used in Biomedical Research:AC-ARG-GLY-LYS(AC)-AMC is used as a research tool for studying histone deacetylase activity. It aids scientists in understanding the role of HDACs in gene regulation and their involvement in diseases such as cancer, neurological disorders, and cardiovascular diseases.
Used in Drug Discovery and Development:
AC-ARG-GLY-LYS(AC)-AMC serves as a valuable assay for the identification and optimization of HDAC inhibitors. These inhibitors have potential therapeutic applications in the treatment of various diseases, including cancer and neurodegenerative disorders. By using this substrate, researchers can screen and evaluate the efficacy of candidate compounds in inhibiting HDAC activity.
Used in Quality Control and Standardization:
AC-ARG-GLY-LYS(AC)-AMC is used as a quality control standard for the assessment of HDAC activity in biological samples. It helps ensure the accuracy and reliability of experimental results, as well as the standardization of HDAC activity measurements across different laboratories and studies.
Used in Educational Settings:
AC-ARG-GLY-LYS(AC)-AMC can be employed as an educational tool in teaching and training programs related to molecular biology, biochemistry, and pharmacology. It provides students and researchers with hands-on experience in conducting enzyme assays and understanding the principles of enzyme kinetics and inhibition.
Check Digit Verification of cas no
The CAS Registry Mumber 660846-97-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,0,8,4 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.Calculate Digit Verification of CAS Registry Number 660846-97:
(8*6)+(7*6)+(6*0)+(5*8)+(4*4)+(3*6)+(2*9)+(1*7)=189
189 % 10 = 9
So 660846-97-9 is a valid CAS Registry Number.
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AC-ARG-GLY-LYS(AC)-AMC
