66094-91-5

Upstream product

• 153-61-7 cephalothin 
• 908093-98-1 diazodiphenylmethane 
• 35607-83-1 (6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 50-00-0 formaldehyd 
• 90026-87-2 benzhydryl 7-(2-thienyl)acetamido-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide 

Downstream Products

• 66094-94-8 (4'R)-3'-acetoxymethyl-5't,8'-dioxo-7't-(2-thiophen-2-yl-acetylamino)-(4'rN,6'cH)-5'λ⁴-spiro[aziridine-2,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid benzhydryl ester 
• 121534-61-0 benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide 
• 121534-61-0 benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide 

Relevant academic research and scientific papers

CYCLOADDITION REACTIONS OF CEPHALOSPORIN COMPOUNDS, X. SYNTHESIS AND STEREOCHEMISTRY OF BENZHYDRYL 7β-(2-THIENYL)ACETAMIDO-2-SPIROCYCLOPROPYL-2(2',2'-DIPHENYL)-3-ACETOXYMETHYL-3-CEPHEM-4-CARBOXYLATE 1S(β)-OXIDE

Cycloadditions are useful methods to synthesize novel β-lactam derivatives .In our laboratory we studied the 1,3-dipolar cycloaddition reactions of 2-methylenecephems with diazoalkanes .In this paper we report the synthesis and structure elucid