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Pergolide mesylate salt is a potent, long-acting dopamine agonist that is primarily used in the treatment of Parkinson's disease and hyperprolactinemia. It is a dopamine D1 and D2 receptor agonist with high affinity for rat striatal receptors (Kis = 111 and 0.495 nM, respectively). Compared to lergotrile, pergolide mesylate exhibits less toxicity and a lower propensity for inducing psychosis.
Used in Pharmaceutical Industry:
Pergolide mesylate salt is used as an antiparkinsonian agent for its ability to depress dopaminergic firing in paralyzed rats, which can be reversed by dopamine D2-selective antagonist spiperone or dopamine D1-selective antagonist SCH 23390. It is also used to increase the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson's disease induced by MPTP.
Additionally, Pergolide mesylate salt is used as a dopaminergic agonist to decrease plasma prolactin concentrations, making it useful in the treatment of hyperprolactinemia. It has been shown to reduce carrageenan-induced paw edema in adrenalectomized rats, further demonstrating its therapeutic potential in various conditions.

66104-23-2

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66104-23-2 Usage

Biochem/physiol Actions

Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent.

Check Digit Verification of cas no

The CAS Registry Mumber 66104-23-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,0 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66104-23:
(7*6)+(6*6)+(5*1)+(4*0)+(3*4)+(2*2)+(1*3)=102
102 % 10 = 2
So 66104-23-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1

66104-23-2 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000010)  Pergolide mesilate  European Pharmacopoeia (EP) Reference Standard

  • 66104-23-2

  • Y0000010

  • 1,880.19CNY

  • Detail

  • USP

  • (1510845)  Pergolide mesylate  United States Pharmacopeia (USP) Reference Standard

  • 66104-23-2

  • 1510845-200MG

  • 5,809.05CNY

  • Detail

66104-23-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name pergolide mesylate

1.2 Other means of identification

Product number -
Other names Pergolide Mesylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66104-23-2 SDS

66104-23-2Downstream Products

66104-23-2Relevant academic research and scientific papers

Development of a practical high-yield industrial synthesis of pergolide mesylate

Cabri, Walter,Roletto, Jacopo,Olmo, Sara,Fonte, Piera,Ghetti, Paolo,Songia, Simonetta,Mapelli, Elio,Alpegiani, Marco,Paissoni, Paolo

, p. 198 - 202 (2012/12/22)

The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with >99.8% purity.

Decyanation of pergolide intermediate

-

, (2008/06/13)

The present invention provides a process for decyanating a pergolide intermediate with an alkali metal hydroxide in an alcoholic solvent having a boiling point greater than about 100° C. at a temperature in the range of about 100° C. to about 175° C.

6-N-Propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds

-

, (2008/06/13)

6-n-Propyl (ethyl or allyl)-8β-methoxy-(methylsulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonism.

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