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Iohexol Contrast Medium
Cas No: 66108-95-0
No Data 1 Kilogram Metric Ton/Day Sunmore Healthcare Co., LTD. Contact Supplier
Iohexol
Cas No: 66108-95-0
No Data 100 Gram 100 Kilogram/Month ShangHai Jin Dun Industrial CO., LTD Contact Supplier
Iohexol
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No Data No Data No Data Beijing Jin Ming Biotechnology Co., Ltd. Contact Supplier
Iohexol, CAS: 66108-95-0, purity 99%, API grade
Cas No: 66108-95-0
No Data 1 Metric Ton Metric Ton/Day Nanjing Yuance Industry&Trade Co., Ltd. Contact Supplier
Iohexol
Cas No: 66108-95-0
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Iohexol Manufacturer/High quality/Best price/In stock
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Iohexol CAS NO. 66108-95-0 USP34 Standard/contrast agent
Cas No: 66108-95-0
No Data 1 Milligram 1000 Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Factory supply Iohexol Cas 66108-95-0 with high quality and favorable price
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No Data 1 Kilogram 15 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Good quality Iohexol
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No Data 1 Kilogram 200 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
CHemwill -- Iohexol
Cas No: 66108-95-0
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier

66108-95-0 Usage

Adverse effects

1. Adverse effects after application in subarachnoid space are generally the same as that of receiving the lumbar puncture, but are mostly mild. The incidence of headache is less than that of using meglumine. Severe headache lasting several days may be intermittent. Other may have nausea, vomiting, dizziness, neck back pain, limb pain and paresthesia. EEG showed no clear short wave.
2. Adverse effects after intravascular administration were significantly lower than those of other ionic contrast agents in frequency and severity, and adverse reactions were similar to that of meglumine. A small number of patients have mild reactions, such as warm feeling, red, nausea, vomiting, mild chest pain, skin itching, urticaria, numbness and lower limbs.

Uses

Imaging agent

Medicine interactions

1, Patients subjecting to metformin treatment, if subjecting to simultaneous injection of iohexol contrast agent, may get lactic acidosis and acute renal failure.
2, Simultaneous administration of tricyclic antidepressants or monoamine oxidase inhibitors during the intrathecal injection of the drug can reduce the threshold of seizures, and lead to seizures.
3. Patients treated with interleukin-2 within 2 weeks had an increased risk of delayed response (cold-like symptoms and skin reactions).
4, Ⅲ antiarrhythmic drugs such as amiodarone, in the recommended dose, can extend the QT interval. The effect of prolonging the QT interval when combined with this product has additive effect.
This information was edited by Chemicalbook (2015-08-03).

Dosage and Usage

Intrathecal injection: Dose should be according to the check project and the usage technical decisions. It can be referred to the following table.
Application items Concentration (mg/ml) Usage amount (ml/per time)
Waist, thoracic
angiography
180
240
0~15
8~12
Cervical angiography
CT scan Cisternography
240
180
240
10~12
5~15
4~12
Myelography for children    
<2 years old
2~6 years old
>6 years old
180
180
180
2~6
4~8
6~12
It can be used for cardiovascular, arterial intravenous and urinary tract radiography. The iodine concentration and dosage used should be generally the same as other angiographic contrast agents currently used.

Definition

ChEBI: A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.

Uses

It is the raw material for the production of water-soluble, non-ionic X-CT contrast agent in pharmaceutical factory. The trade name of this contrast agent is Omnipaque. This contrast agent is usually injected into the vein before CT angiography to be used for angiography, urinary system, spinal cord and joint, lymphatic system angiography, with advantages of low contrast density, low toxicity and good tolerance type. Iohexol is also currently one of the best contrast agents. The developed countries have completely used it to replace ionography agent. It is also a diagnostic drug.
It can be used as non-ionic X-CT contrast agent.

Clinical application

It can be used for angiography, urography, cerebral angiography, peripheral and various kinds of arterial angiography, venography, digital subtraction and CT enhanced scan. Myelography and the use of subarachnoid injection for brain pool CT scan. It can also be applied to various kinds of body cavity examinations.
Subarachnoid space application
①It should be done of iodine allergy test before the application. Patients of positive result should be disabled. Patients of a history of epilepsy should be disabled.
②Patients having a history of allergies or being suspected allergic to this product, but must be subject to the angiography of this product can choose to apply adrenal cortex hormones and antihistamines before the contrast to prevent. But the spinal cord should be disabled of applying adrenal corticosteroid drugs.
③Patients of local or systemic bacterial infection should not carry out lumbar puncture, of course, can’t use this product for angiography.
④If necessary, it can be given of sedation agents such as diazepam before surgery. Upon severe pain, it can be administrated of analgesics.
⑤Good body fluid condition can reduce the incidence of adverse reactions, therefore it should be prevented of dehydration of patients.
⑥After angiography, allow the patients to sit in bed. The head should be elevated for at least 6 hours. The patient should maintain the supine position for 24 hours without self-move or bending down to prevent the residual contrast agent from flowing into the brain and reduce the leakage of cerebrospinal fluid.
⑦If the patients get nausea, vomiting, it should be applied of intravenous fluids to replace the fluid food; if necessary, it should be given of antiemetic.
⑧Upon myelography failure, it is not appropriate for immediate repeated angiography.
⑨Upon seizures, it should be immediately applied of intravenous injection of 10mg diazepam. To prevent recurrence of epilepsy, it can be applied of intramuscular injection of 0.2 g phenobarbital sodium at 20 to 30 minutes after the stopping of pathogenesis.
⑩The relative density of iohexol injection should be higher than that of cerebrospinal fluid.

Precautions

1, Patients with allergic history to iodine and allergic constitution should take with caution.
2, Patients of liver and kidney dysfunction, heart and circulatory system dysfunction, physical weakness, cerebral arteriosclerosis, diabetes, goiter and leukemia should take with caution.
3, Patients of severe hyperthyroidism should be disabled.
4, generally it should be prepared well of acute allergic reactions rescue.
Chemical properties
It appears as white or light gray powder with hygroscopicity.

Pharmacological effects

Iohexol contrast agent belongs to non-ionic water-soluble contrast agent with a similar osmotic pressure with plasma as well as moderate viscosity. It is easily for injection. Clinical angiography and urography have proved less toxic than ionic contrast agents, and can be safely used for myelography. The reason is that the non-ionic contrast agent has weak stimulation on the mast cell with less histamine release and less likely to cause allergic reactions. This product is weak vasodilator, not easy to cause hypotension; it causes very small injury on vascular endothelium, difficult to form thrombosis; small effect on heart and kidney function. It has a lower toxicity than amikacin. This product almost does not penetrate the cell membrane. After intravenous injection, it is mainly distributed in the interstitial cavity without being absorbed by organ and tissue. It is not metabolized by the body and is released mostly with the urine in the prototype form. PBP is smaller than 20%.
Non-ionic intravascular contrast agents: such as iobitridol, ioversol, iodohexol, iopamidol, iopromide and iodixanol.

Intravascular applications

①Before use, it should be applied of allergy testing. Positive patients should be disabled.
②Patients having a history of allergy, being allergic to iodine, of asthma should be disabled or used with caution.
③Patients of severe liver and kidney dysfunction, severe thyroid disease, bone marrow leukemia should be used with caution; These patients should be disabled upon dehydration. Patients of diabetes having a serum creatinine concentration of more than 0.5mmol /L should be disabled.
④pregnant women should be used with caution. Under conditions that it must be applied, it should be used of the lowest dose.
⑤This product can interfere with thyroid function tests, so that the ability of thyroid tissue  binding to iodine will be reduced, and it should be taken of several days or even two weeks for fully recover.
⑥contrast agent should not be mixed with other drugs for compatibility, instead should be used of a dedicated syringe.

Uses

antibacterial

Chemical Properties

White Solid

Non-ionic contrast agent

Iohexol is a non-ionic contrast agent with its pure product appearing as white or light gray powder and having hygroscopicity. In the early 80s of last century, it has been successfully developed by the Nycomed Company (Norwegian) and has first entered into market in 1982 in Norway and Sweden. In 1985, it has obtained the approval of the US Food and Drug Administration (FDA) for entering into US market; in the early 90s, Schering AG and Japan's first pharmaceutical Co., Ltd. were respectively subject to transferee production with product sales in Europe and the Asia-Pacific countries.
The six hydroxyl groups in its molecules are evenly distributed around the benzene ring, effective shielding the lipophilic iodobenzene ring, making it have high hydrophilic, low viscosity, low permeability than ordinary ion-type contrast agent and low toxicity against the nerve system, etc. It is the raw material for the production of water-soluble, non-ionic X-CT contrast agent in pharmaceutical factory. Iohexol is also currently one of the best contrast agents. The developed countries have completely used it to replace ionography agent. It is suitable for myelography, cardiovascular, arteriovenous, lymphatic system, urography and enhanced CT scan. The general dosage is as follows: decision regarding spinal canal imaging is based on the location; lumbar thoracic 24% solution: 8~12ml, neck 24% solution: 10~15ml, CT scan Cisternography 8~12ml.

Brand name

Omnipaque (GE Healthcare).

66108-95-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1344600)  Iohexol  United States Pharmacopeia (USP) Reference Standard 66108-95-0 1344600-200MG 4,779.45CNY Detail
Sigma-Aldrich (Y0000672)  Iohexol for peak identification  European Pharmacopoeia (EP) Reference Standard 66108-95-0 Y0000672 1,880.19CNY Detail
Sigma-Aldrich (I0320800)  Iohexol  European Pharmacopoeia (EP) Reference Standard 66108-95-0 I0320800 1,880.19CNY Detail
Sigma-Aldrich (74147)  Iohexol  analytical standard 66108-95-0 74147-50MG 758.16CNY Detail
TCI America (I0903)  Iohexol (mixture of isomers)  >98.0%(HPLC)(N) 66108-95-0 25g 1,480.00CNY Detail
TCI America (I0903)  Iohexol (mixture of isomers)  >98.0%(HPLC)(N) 66108-95-0 5g 430.00CNY Detail

66108-95-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name iohexol

1.2 Other means of identification

Product number -
Other names omnipaqueTM

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66108-95-0 SDS

66108-95-0Synthetic route

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

epichlorohydrin
106-89-8

epichlorohydrin

A

iohexol
66108-95-0

iohexol

B

iodixanol
92339-11-2

iodixanol

Conditions
ConditionsYield
With hydrogenchloride; boric acid; potassium hydroxide In water pH=10 - 11; Product distribution / selectivity; Industry scale;A 7.5%
B 86.3%
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In methanol at 45℃;
Stage #2: epichlorohydrin With hydrogenchloride In methanol at 20℃; for 48h; Product distribution / selectivity;
A 7.42%
B 52.1%
With hydrogenchloride; sodium hydroxide In water at 20℃; for 48h; pH=12.2 - 12.7;A 5.1%
B 43.5%
3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In 2-(2-methoxyethoxy)ethyl alcohol; water at 44 - 60℃;
Stage #2: 3-monochloro-1,2-propanediol In 2-(2-methoxyethoxy)ethyl alcohol; water at 29 - 31℃; for 21h;
Stage #3: With hydrogenchloride In 2-(2-methoxyethoxy)ethyl alcohol; water pH=4 - 5; Product distribution / selectivity;
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In 2-(2-methoxyethoxy)ethyl alcohol; water at 44 - 60℃;
Stage #2: 3-monochloro-1,2-propanediol In 2-(2-methoxyethoxy)ethyl alcohol; water at 29 - 31℃; for 21h;
Stage #3: With acetic acid In 2-(2-methoxyethoxy)ethyl alcohol; water Product distribution / selectivity;
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

butan-1-ol
71-36-3

butan-1-ol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
With sodium hydroxide; Ca(OH)2 In water
With sodium hydroxide; Ca(OH)2 In water
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

iohexol
66108-95-0

iohexol

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

oxiranyl-methanol
556-52-5

oxiranyl-methanol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
With potassium hydroxide In methanol; dimethyl sulfoxide; isopropyl alcohol
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With boric acid; potassium hydroxide In water at 10℃; for 48h; pH=12.4;
Stage #2: oxiranyl-methanol In water at 10℃; for 24h; pH=12.6-13; Time; pH-value;
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
With sodium methylate In propylene glycol
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In methanol; 1-methoxy-2-propanol at 25 - 45℃;
Stage #2: 3-monochloro-1,2-propanediol In methanol; 1-methoxy-2-propanol at 25℃; for 25.5h; Product distribution / selectivity;
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In 1-methoxy-2-propanol; water at 25 - 45℃;
Stage #2: 3-monochloro-1,2-propanediol In 1-methoxy-2-propanol; water at 35℃; for 27h; Product distribution / selectivity;
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

A

iohexol
66108-95-0

iohexol

B

iodixanol
92339-11-2

iodixanol

Conditions
ConditionsYield
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In methanol at 45℃;
Stage #2: With hydrogenchloride In methanol; water at 15℃; for 48h; Product distribution / selectivity;
5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
76801-93-9

5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 26 h / 65 - 70 °C / Green chemistry
2: sodium methylate / methanol / 40 °C / Green chemistry
3: methanol / 72 h / 20 °C / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1.1: 65 - 70 °C / Green chemistry
2.1: hydrogenchloride / methanol / 3 h / Green chemistry
3.1: sodium methylate / methanol / 40 °C / Green chemistry
3.2: 72 h / 20 °C / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid / water / 50 - 100 °C
2: sodium hydroxide; water / 20 °C / pH 9 - 11
3: sodium hydroxide / 1,2-dimethoxyethane / 30 - 100 °C
View Scheme
5-Amino-N,N'-bis[2,3-dihydroxypropyl]-1,3-benzenedicarboxamide
76820-35-4

5-Amino-N,N'-bis[2,3-dihydroxypropyl]-1,3-benzenedicarboxamide

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Iodine monochloride / 6 h / 50 °C
2: sulfuric acid / water / 50 - 100 °C
3: sodium hydroxide; water / 20 °C / pH 9 - 11
4: sodium hydroxide / 1,2-dimethoxyethane / 30 - 100 °C
View Scheme
5-nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide
76820-34-3

5-nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 5%-palladium/activated carbon; hydrogen / 70 °C / 9000.9 Torr / Autoclave
2: Iodine monochloride / 6 h / 50 °C
3: sulfuric acid / water / 50 - 100 °C
4: sodium hydroxide; water / 20 °C / pH 9 - 11
5: sodium hydroxide / 1,2-dimethoxyethane / 30 - 100 °C
View Scheme
dimethyl 5-nitroisophthalate
13290-96-5

dimethyl 5-nitroisophthalate

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium methylate / methanol / 20 - 50 °C
2: 5%-palladium/activated carbon; hydrogen / 70 °C / 9000.9 Torr / Autoclave
3: Iodine monochloride / 6 h / 50 °C
4: sulfuric acid / water / 50 - 100 °C
5: sodium hydroxide; water / 20 °C / pH 9 - 11
6: sodium hydroxide / 1,2-dimethoxyethane / 30 - 100 °C
View Scheme
iohexol
66108-95-0

iohexol

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
With lithium hydroxide In methanol92%
iohexol
66108-95-0

iohexol

N,N'-bis(2,3-dihydroxypropyl)-3,4-dihydro-2-hydroxymethyl-5,7-diiodo-2H-1,4-benzoxazine-6,8-dicarboxamide

N,N'-bis(2,3-dihydroxypropyl)-3,4-dihydro-2-hydroxymethyl-5,7-diiodo-2H-1,4-benzoxazine-6,8-dicarboxamide

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 12h; Reagent/catalyst; Temperature; Inert atmosphere;80%
(S)-2,2',2'',2'''-(2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
1020407-41-3

(S)-2,2',2'',2'''-(2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid

iohexol
66108-95-0

iohexol

p-SCN-Bn-DOTA-iohexol

p-SCN-Bn-DOTA-iohexol

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Inert atmosphere;75%
iohexol
66108-95-0

iohexol

5-[N-(2,3-dihydroxypropyl)acetamido]-N,N'-bis(2,3-dihydroxypropyl)-2,4-diiodo-1,3-benzenedicarboxamide

5-[N-(2,3-dihydroxypropyl)acetamido]-N,N'-bis(2,3-dihydroxypropyl)-2,4-diiodo-1,3-benzenedicarboxamide

Conditions
ConditionsYield
With sodium tetrahydroborate In water at 15 - 35℃; Reagent/catalyst;59.06%
iohexol
66108-95-0

iohexol

C19H26I3N3O9*Mg(2+)

C19H26I3N3O9*Mg(2+)

Conditions
ConditionsYield
With magnesium chloride In water

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