66129-51-9Relevant academic research and scientific papers
Direct access to benzofuro[2,3-: B] quinoline and 6 H -chromeno[3,4- b] quinoline cores through gold-catalyzed annulation of anthranils with arenoxyethynes and aryl propargyl ethers
Patil, Manoj D.,Liu, Rai-Shung
supporting information, p. 4452 - 4455 (2019/05/16)
This work reports a facile annulation of anthranils with aryloxyethynes or aryl propargyl ethers to construct useful benzofuro[2,3-b]quinoline and 6H-chromeno[3,4-b]quinoline frameworks, respectively; these heterocycles are not readily available from literature methods despite their biological significance. This high atom- and step-economy strategy is highlighted by a broad substrate scope. The reaction mechanism is proposed to proceed through sequential cyclizations among the oxyaryl group, gold carbene and benzaldehyde of the α-imino gold carbene intermediates.
