66130-01-6Relevant academic research and scientific papers
Iron-catalysed 1,2-aryl migration of tertiary azides
Wei, Kaijie,Yang, Tonghao,Chen, Qing,Liang, Siyu,Yu, Wei
, p. 11685 - 11688 (2020/10/19)
1,2-Aryl migration of α,α-diaryl tertiary azides was achieved by using the catalytic system of FeCl2/N-heterocyclic carbene (NHC) SIPr·HCl. The reaction generated aniline products in good yields after one-pot reduction of the migration-resultant imines.
Friedel-Crafts alkylation of benzene with 1,2-diphenyl-2-propanol, 1-chloro-2,3-diphenylpropane and 2-methyl-1-phenyl-2-butanol
Khalaf, Ali A.,Awad, Ibrahim M.,El-Emary,El-Aal, H.A.K. Abd
experimental part, p. 595 - 600 (2011/08/21)
The alkylation of benzene with 1,2-diphenyl-2-propanol (1) using AlCl 3/CH3NO2 catalyst gave a mixture of 1,2,2- (4) and 1,1,2-triphenylpropane (5) as product alkylates. With 85% H 2SO4 catalyst, the product consisted of E-1,2-diphenylpropene (6) after 2 h of a mixture of 5 and 6 after 18 h. Similar alkylation of benzene with 1-chloro-2,3-diphenylpropane (2) using AlCl 3 catalyst gave a mixture consisting of 4, 5 and 6. Finally, alkylation of benzene with 2-methyl-1-phenyl-2-butanol (3) using AlCl 3/CH3NO2 gave 2-methyl-1,1-diphenylbutane (10) as sole product alkylate. The identities of the products were confirmed spectroscopically and by comparison with unequivocally prepared samples. Mechanisms are proposed to rationalise the observed results.
Highly efficient alkylation to ketones and aldimines with Grignard reagents catalyzed by zinc(II) chloride
Hatano, Manabu,Suzuki, Shinji,Ishihara, Kazuaki
, p. 9998 - 9999 (2007/10/03)
A highly efficient alkylation to ketones and aldimines with Grignard reagents in the presence of catalytic trialkylzinc(II) ate complexes derived from ZnCl2 (10 mol %) in situ was developed. This simple Zn(II)-catalyzed alkylation could minimize the well-known but serious problems with the use of only Grignard reagents, which leads to reduction and aldol side products, and the yield of desired alkylation products could be improved. Copyright
A comparative product investigation between Grignard reactions of benzophenone and coupling reactions of electrogenerated benzophenone radical anions and alkyl radicals in THF
Lund, Torben,Ohlrich, Ditte,Borling, Pernille
, p. 932 - 937 (2007/10/03)
The 1,6-to 1,2-addition product ratios of the Grignard reactions of benzophenone with t-, s- and n-C4H9MgCl have been compared with the corresponding ratios obtained by the electrolysis of benzophenone in presence of t-, s- and n-C4H9S+(CH3)2, ClO4-in THF. The Grignard reaction ratios 0.81, 0.50 and 0.19, respectively, were obtained whereas the corresponding electrolysis ratios were 2.26, 1.23 and 1.61. From this comparison of product ratios it is concluded that none of the Grignard reactions of benzophenone proceeds through a complete free coupling process of benzophenone radical anions and butyl radicals. The ET character of the Grignard reactions of benzophenone with t-, s- and n-C4H9MgCl was estimated to be 65, 61 and 26%, respectively.
Electrochemical alkyl transfer reactions of trialkylborane to carbonyl compounds by use of copper sacrificial anode
Choi, Jung Hoon,Youm, Jong Sung,Cho, Cheon-Gyu,Czae, Myung-Zoon,Hwang, Book Kee,Kim, Jung Sung
, p. 4835 - 4838 (2007/10/03)
Alkyl groups in trialkylboranes were successfully transferred to carbonyl compounds in the presence of the platinum cathode and copper anode by electrochemical method. The new, mild electrochemical alkyl transfer reaction produced various substituted alcohols in good yields.
ALKYL AND ARYLLANTHANUM TRIFLATES: NEW REAGENTS FOR THE CONVERSION OF TERTIARY AMIDES TO KETONES
Collins, Scott,Hong, Yaping
, p. 4391 - 4394 (2007/10/02)
Alkyl and aryllanthanum triflates 1 generated in situ from alkyl or aryllithium compounds and anhydrous lanthanum(III) triflate react with tertiary amides to provide, in excellent yield, the corresponding alkyl or aryl ketones.
