66134-18-7

Basic information

• Product Name: 1H,1'H-[5,5']Biindolyl
• Synonyms: 5,5'-Bi-1H-indole;1H,1'H-5,5'-biindole;1H,1'H-[5,5']Biindolyl
• CAS NO: 66134-18-7
• Molecular Formula: C16H12N2
• Molecular Weight: 232.28
• Mol File: 66134-18-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 195 °C(Solv: chloroform (67-66-3))
• Boiling Point: 523.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• PKA: 16.59±0.30(Predicted)
• CAS DataBase Reference: 1H,1'H-[5,5']Biindolyl(CAS DataBase Reference)
• NIST Chemistry Reference: 1H,1'H-[5,5']Biindolyl(66134-18-7)
• EPA Substance Registry System: 1H,1'H-[5,5']Biindolyl(66134-18-7)

Safety Data

• Hazardous Substances Data: 66134-18-7(Hazardous Substances Data)

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 269410-24-4 5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 144104-59-6 1H-indole-5-boronic acid 
• 17422-32-1 5-chloro-1H-indole 

Downstream Products

• 1613153-73-3 3-[[5-[3-[(3-methoxycarbonylphenyl)methyl]-1H-indol-5-yl]-1H-indol-3-yl]methyl]benzoic acid 
• 1613153-94-8 methyl 3-[[5-[3-[(3-methoxycarbonylphenyl)methyl]-1H-indol-5-yl]-1H-indol-3-yl]methyl]benzoate 

Relevant articles and documents

Bimetallic Au-Pd nanochain networks: Facile synthesis and promising application in biaryl synthesis

A simple and facile method is described for the morphology-controlled synthesis of bimetallic Au-Pd alloyed nanochain networks (NNCs) that show high catalytic performance for the Ullmann intermolecular homocoupling of aromatic or alkyl halides (X = I, Br, Cl) in aqueous media and can be reused at least five times, which can also be applied to intramolecular homocoupling.

Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41

We previously described indole-containing compounds with the potential to inhibit HIV-1 fusion by targeting the hydrophobic pocket of transmembrane glycoprotein gp41. Here we report optimization and structure-activity relationship studies on the basic scaffold, defining the role of shape, contact surface area, and molecular properties. Thirty new compounds were evaluated in binding, cell-cell fusion, and viral replication assays. Below a 1 μM threshold, correlation between binding and biological activity was diminished, indicating an amphipathic requirement for activity in cells. The most active inhibitor 6j exhibited 0.6 μM binding affinity and 0.2 μM EC50 against cell-cell fusion and live virus replication and was active against T20 resistant strains. Twenty-two compounds with the same connectivity displayed a consensus pose in docking calculations, with rank order matching the biological activity. The work provides insight into requirements for small molecule inhibition of HIV-1 fusion and demonstrates a potent low molecular weight fusion inhibitor.

FeCl3 catalyzed barbier homocoupling reaction for synthesis of symmetric biaryls

Aseries of biaryls and biheteroaryls were synthesized by the Barbier reaction of aryl bromide withmagnesium powder and 1,2-dibromoethane in the presence of FeCl3 in THF under reflux reaction condition. The catalytic system differentiates itself fromother homocoupling reactions catalyzed by iron salts in that it requires neither the preliminary preparation of Grignard reagent nor the addition of an oxidant.