66142-75-4Relevant academic research and scientific papers
Synthesis of Highly Substituted Phenols and Benzenes with Complete Regiochemical Control
Zhang, Xiaojie,Beaudry, Christopher M.
supporting information, p. 6086 - 6090 (2020/08/12)
Substituted phenols are requisite molecules for human health, agriculture, and diverse synthetic materials. We report a chemical synthesis of phenols, including penta-substituted phenols, that accommodates programmable substitution at any position. This method uses a one-step conversion of readily available hydroxypyrone and nitroalkene starting materials to give phenols with complete regiochemical control and in high chemical yield. Additionally, the phenols can be converted into highly and even fully substituted benzenes.
ORTHO-METHYLATION OF PHENOLS WITH ETHYL(IODOMETHYL)ZINC
Lehnert, Erich K.,Sawyer, J. Scott,Macdonald, Timothy L.
, p. 5215 - 5218 (2007/10/02)
The regioselective ortho-methylation of phenols by in situ generated ethyl(iodomethyl)zinc via an internal alkylation process is described.
