661466-54-2Relevant academic research and scientific papers
Artemisinin derivatives bearing Mannich base group: Synthesis and antimalarial activity
Li, Ying,Yang, Zhong-Shun,Zhang, Hong,Cao, Ben-Jun,Wang, Fang-Dao,Zhang, Yu,Shi, Yun-Lin,Yang, Jun-De,Wu, Bo-An
, p. 4363 - 4368 (2003)
Novel artemisinin derivatives bearing Mannich base group were prepared and tested for their antimalarial activity. These water-soluble artemisinin derivatives were more stable than sodium artesunate and few compounds were found to be more active against Plasmodium berghei in mice than artesunic acid by oral administration. Two most potent derivatives 17b and 17d were examined for their antimalarial activity against Plasmodium knowlesi in rhesus monkeys.
ARTEMISINE (QINGHAOSU) DERIVATIVES, THEIR PREPARATION METHODS AND THEIR USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
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Page/Page column 8, (2008/06/13)
The invention provides a type of artemisinin derivatives having following structure I, its preparation method and use, as well as a pharmaceutical composition containing such artemisinin derivatives and its use. The arteminsinin derivatives of the present
